Evidence map›Paper›PMID 29154829›Full record

ArticleBiochemical and biophysical research communications2018

A role for Candida albicans superoxide dismutase enzymes in glucose signaling.

Chynna N Broxton, Bixi He, Vincent M Bruno, Valeria C Culotta

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Chemoproteomic Profiling ofJournal of medicinal chemistry · 2025
    Article
  2. Chemoproteomic Profiling ofbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chynna N BroxtonDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Bixi HeDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Vincent M BrunoDepartment Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, 801 W. Baltimore St, Baltimore, MD 21201, USA.
Valeria C CulottaDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: vculott1@jhu.edu.
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
GENETIC DETERMINANTS OF OXYGEN TOXICITYR01GM050016 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 1993 to 2018
$3.0M
Copper as a nutrient for Candida albicans at the host-pathogen interfaceR01AI119949 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 2015 to 2019
$2.3M
NCI NIH HHS T32 CA009110NIAID NIH HHS R01 AI119949NIAID NIH HHS U19 AI110820NIGMS NIH HHS R01 GM050016
6 · The paper itself

Abstract

The Saccharomyces cerevisiae and Candida albicans yeasts have evolved to differentially use glucose for fermentation versus respiration. S. cerevisiae is Crabtree positive, where glucose represses respiration and promotes fermentation, while the opportunistic fungal pathogen C. albicans is Crabtree negative and does not repress respiration with glucose. We have previously shown that glucose control in S. cerevisiae involves the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1), where H

Indexed as

Candida albicansGene Expression Regulation, EnzymologicGene Expression Regulation, FungalGlucoseSignal TransductionSpecies SpecificitySuperoxide DismutaseSuperoxide Dismutase-1GlucoseSuperoxide DismutaseSuperoxide Dismutase-1Candida albicansGlucoseSuperoxide dismutaseYeast

Identifiers

PMID29154829
PMCPMC5956524
OpenAlexW2770007559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.