ArticleHormones and behavior2018
Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels.
Article in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review.Frontiers in endocrinology · 2022Pooled it
- Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.Environment international · 2021Pooled it
- Associations of Prenatal Exposure to Triclosan and Maternal Thyroid Hormone Levels: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Endocrine-disrupting chemicals in cosmetics: mechanistic insights and their impact on human and skin health.Reviews in endocrine & metabolic disorders · 2026Review
- A Point-of-Use Assay Based on Surface-Enhanced Raman Spectroscopy for Rapid Determination of Triclosan in Environmental Water and Mouthwash.ACS omega · 2025Article
- Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions.Frontiers in endocrinology · 2024Review
- Early-life exposure to tobacco and childhood adiposity: Identifying windows of susceptibility.Pediatric obesity · 2022Article
- Triclosan and Its Consequences on the Reproductive, Cardiovascular and Thyroid Levels.International journal of molecular sciences · 2022Review
- Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022Review
- Effect of Maternal Triclosan Exposure on Neonatal Thyroid-Stimulating Hormone Levels: A Cross-Sectional Study.Journal of environmental and public health · 2022Article
- Gestational and childhood urinary triclosan concentrations and academic achievement among 8-year-old children.Neurotoxicology · 2020Article
- The Impact of Early-Life Exposure to Antimicrobials on Asthma and Eczema Risk in Children.Current environmental health reports · 2019Review
- Early-life triclosan exposure and parent-reported behavior problems in 8-year-old children.Environment international · 2019Article
- A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.Environmental health : a global access science source · 2019Article
- Statistical Approaches for Investigating Periods of Susceptibility in Children's Environmental Health Research.Current environmental health reports · 2019Review
- Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.Environment international · 2019Article
- Associations of maternal exposure to triclosan, parabens, and other phenols with prenatal maternal and neonatal thyroid hormone levels.Environmental research · 2018Article
- Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.Environmental health perspectives · 2018Article
- Prenatal urinary triclosan concentrations and child neurobehavior.Environment international · 2018Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundTriclosan, an antimicrobial agent used in some consumer products, reduces endogenous thyroid hormone concentrations in rodents. Despite ubiquitous triclosan exposure and the importance of thyroid hormones for normal fetal development, few human studies have examined the impact of triclosan exposure on maternal, neonatal, or child thyroid hormones.
methodsIn the HOME Study, a prospective cohort from Cincinnati, OH, we measured urinary triclosan concentrations up to three times in pregnant women between 16weeks and delivery, and up to three times in children between age 1-3years. We quantified serum concentrations of thyroid stimulating hormone and total and free thyroxine and triiodothyronine in mothers at 16-weeks gestation (n=202), neonates at delivery (n=274), and children at age 3years (n=153). We estimated covariate-adjusted differences in thyroid hormones with a 10-fold increase in triclosan using linear regression and multiple informants models.
resultsTriclosan was not associated with thyroid hormones during pregnancy. We observed a few associations of triclosan concentrations with thyroid hormone concentrations in neonates at delivery and children at age 3years. Higher gestational triclosan, particularly around the time of delivery, was associated with lower cord serum total thyroxine (β: 0.3μg/dL; 95% CI: -0.6, -0.0). Childhood triclosan, particularly at age 1year, was positively associated with total thyroxine at age 3years (β: 0.7μg/dL; 95% CI: 0.3, 1.2).
conclusionOur findings suggest that triclosan exposure may influence some features of neonatal and early child thyroid function. Given the large number of comparisons we made, these findings should be replicated in other cohorts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.