ArticleJournal of abnormal psychology2017
HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.
Article in Journal of abnormal psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Independent, Multiplicative, and Cumulative Effects of Recent Stressful Life Events and Adverse Childhood Events on Depressive Symptoms among College Students: Moderation by the HPA-axis Multilocus Genetic Variation.Journal of youth and adolescence · 2025Article
- Protocol for project MHISS: Mental Health and Immunodynamics of Social Stress.Brain, behavior, & immunity - health · 2025Article
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- The Effects of Variation in the GABANeuropsychiatric disease and treatment · 2024Article
- Hypothalamic-pituitary-adrenal Axis Multilocus Genetic Variation, Childhood Parenting and Adolescent Anxiety Symptoms: Evidence of Cumulative Polygenic Plasticity.Journal of youth and adolescence · 2022Article
- The Role of Social Position Within Peer Groups in Distress-Motivated Smoking Among Adolescents.Journal of studies on alcohol and drugs · 2022Article
- Beyond WEIRD: Associations between socioeconomic status, gender, lifetime stress exposure, and depression in Madagascar.Journal of clinical psychology · 2021Article
- Hippocampal subregion volume in high-risk offspring is associated with increases in depressive symptoms across the transition to adolescence.Journal of affective disorders · 2021Article
- HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood.Development and psychopathology · 2021Article
- Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation.Development and psychopathology · 2020Article
- Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression.Depression and anxiety · 2020Article
- The role of familial risk, parental psychopathology, and stress for first-onset depression during adolescence.Journal of affective disorders · 2019Article
- Individual differences in developmental plasticity: A role for early androgens?Psychoneuroendocrinology · 2018Review
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6 authors.
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Abstract
Although offspring of depressed mothers are at an increased risk for depression themselves, not all of these children develop depression, highlighting the need to identify specific environmental and genetic moderators of risk. The goal of this study was to examine the aggregate influence of genetic polymorphisms associated with the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as a potential moderator of the relation between environmental stress and prospective changes in depressive symptoms for offspring of depressed mothers. Participants were 238 mother-offspring dyads recruited from the community based on the mother's lifetime history of major depression during the youth's lifetime (present vs. absent). Mothers and youth completed assessments every 6 months for 2 years (5 total). Results indicated that offspring of depressed mothers showing the greatest increases in depressive symptoms during the follow up were those who had higher HPA multilocus genetic profile scores and who experienced the highest levels of interpersonal stress. These relations were significant for interpersonal stress and were not observed for noninterpersonal stress. These findings suggest that HPA multilocus genetic profile scores may be important genetic markers of stress reactivity and depression risk for offspring of depressed mothers. They also highlight interpersonal stress as a potentially modifiable risk factor for these high-risk youth. (PsycINFO Database Record
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