Evidence map›Paper›PMID 29154434›Full record

ArticleESC heart failure2017

Right ventricular involvement in cardiac sarcoidosis demonstrated with cardiac magnetic resonance.

Jan-Peter Smedema, Robert-Jan van Geuns, Gillian Ainslie, Joris Ector, Hein Heidbuchel, Harry J G M Crijns

Abstract read
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020
    Review
  14. Article
  15. Article
  16. Observational
  17. Echocardiography in Sarcoidosis.Current cardiology reports · 2018
    Review
  18. Updates on the Role of Imaging in Cardiac Sarcoidosis.Current treatment options in cardiovascular medicine · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jan-Peter SmedemaDepartment of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Robert-Jan van GeunsDepartment of Cardiology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Gillian AinslieRespiratory Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa.
Joris EctorDepartment of Cardiology, University Hospitals Gasthuisberg, Leuven, Belgium.
Hein HeidbuchelUniversity of Hasselt Heart Centre, Virga Jessa Hospital, Hasselt, Belgium.
Harry J G M CrijnsDepartment of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCardiac involvement in sarcoidosis is reported in up to 30% of patients. Left ventricular involvement demonstrated by contrast-enhanced cardiac magnetic resonance has been well validated. We sought to determine the prevalence and distribution of right ventricular late gadolinium enhancement in patients diagnosed with pulmonary sarcoidosis. METHODS AND

resultsWe prospectively evaluated 87 patients diagnosed with pulmonary sarcoidosis with contrast-enhanced cardiac magnetic resonance for right ventricular involvement. Pulmonary artery pressures were non-invasively evaluated with Doppler echocardiography. Patient characteristics were compared between the groups with and without right ventricular involvement, and right ventricular enhancement was correlated with pulmonary hypertension, ventricular mass, volume, and systolic function. Left ventricular late gadolinium enhancement was demonstrated in 30 patients (34%). Fourteen patients (16%) had right ventricular late gadolinium enhancement, with sole right ventricular enhancement in only two patients. The pattern of right ventricular enhancement consisted of right ventricular outflow tract enhancement in 1 patient, free wall enhancement in 8 patients, ventricular insertion point enhancement in 10 patients, and enhancement of the right side of the interventricular septum in 11 patients. Pulmonary arterial hypertension correlated with the presence of right ventricular enhancement (P < 0.001). Right ventricular enhancement correlated with systolic ventricular dysfunction (P < 0.001), hypertrophy (P = 0.001), and dilation (P < 0.001).

conclusionsRight ventricular enhancement was present in 16% of patients diagnosed with pulmonary sarcoidosis and in 48% of patients with left ventricular enhancement. The presence of right ventricular enhancement correlated with pulmonary arterial hypertension, right ventricular systolic dysfunction, hypertrophy, and dilation.

Indexed as

CardiomyopathiesEchocardiography, DopplerFemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedRetrospective StudiesSarcoidosisStroke VolumeVentricular Function, RightCardiomyopathyMagnetic resonance imagingPulmonary hypertensionRight ventricleSarcoidosis

Identifiers

PMID29154434
PMCPMC5695200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.