Evidence map›Paper›PMID 29154415›Full record

ArticleESC heart failure2017

Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure.

Kentaro Jujo, Yuichiro Minami, Shintaro Haruki, Yuya Matsue, Kensuke Shimazaki, Hiromu Kadowaki, Issei Ishida, Keigo Kambayashi, Hiroyuki Arashi, Haruki Sekiguchi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
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  19. BUN level is associated with cancer prevalence.European journal of medical research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kentaro JujoDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.ORCID 0000-0002-2011-8204
Yuichiro MinamiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Shintaro HarukiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Yuya MatsueDepartment of Cardiology, Kameda Medical Center, Kamogawa, Japan.
Kensuke ShimazakiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Hiromu KadowakiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Issei IshidaDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Keigo KambayashiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Hiroyuki ArashiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Haruki SekiguchiDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Nobuhisa HagiwaraDepartment of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Tokyo Women's Medical University · JPKameda Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe association between kinetics of blood urea nitrogen (BUN) levels in hospital and cardiovascular outcomes in patients with acutely decompensated congestive heart failure (HF) is unclear. We aimed to estimate the impact of changes in BUN level during hospitalization on clinical prognosis in patients with acute HF. METHODS AND

resultsA total of 353 consecutive patients that were urgently hospitalized due to acutely decompensated HF and discharged alive were divided into four subgroups depending on their BUN level at admission and discharge, using a cut-off level of 21.0 mg/dL. Among 206 patients with high baseline BUN level, 46 (22%) and 160 (78%) had normal and persistent high BUN levels at discharge, respectively. In contrast, of the 147 patients with normal baseline BUN level, 55 (37%) and 92 (63%) had high and normal BUN levels at discharge, respectively. During the observational period after discharge, Kaplan-Meier analysis showed the highest rate of combined outcome of cardiovascular death and HF readmission in patients with persistent high BUN (log-rank test: P < 0.001). After adjustment for comorbidities, the hazard ratio for a combined outcome was significantly lower in patients with normalized BUN level compared with those with persistent high BUN (hazard ratio 0.48, 95% confidence interval 0.23-0.99, P = 0.049).

conclusionsPersistent high BUN levels in hospital are associated with an increased risk of cardiovascular death and HF readmission. Normalization of BUN levels during hospitalization may be associated with long-term clinical outcomes.

Indexed as

Blood Urea NitrogenRisk AssessmentAcute DiseaseAgedBiomarkersDisease ProgressionFemaleFollow-Up StudiesGlomerular Filtration RateHeart FailureHumansIncidenceJapanKaplan-Meier EstimateMalePrognosisBiomarkersAcute heart failureBlood urea nitrogenCardiovascular event

Identifiers

PMID29154415
PMCPMC5695177
OpenAlexW2728006783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.