ArticleAllergy2018
Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls.
Article in Allergy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Measurement of diamine oxidase (DAO) during low-histamine or ordinary diet in patients with histamine intolerance.European journal of clinical nutrition · 2024Trial
- Diamine Oxidase and Gastrointestinal Diseases.Biomolecules · 2026Review
- Is histamine intolerance a treatable subtype of fibromyalgia? evidence and clinical implications-narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Food-derived molecules as regulators of intestinal tight junctions and barrier function: mechanisms and implications.Frontiers in drug delivery · 2026Review
- Improvement of Histamine Intolerance Symptoms in Pregnant Women with Diamine Oxidase Deficiency: An Exploratory Study.Journal of clinical medicine · 2025Article
- Comorbidity of Histamine Intolerance and Polyvalent Allergy: A Case Report and Literature Review.Healthcare (Basel, Switzerland) · 2025Article
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond.Nutrients · 2024Review
- Pilot Study on the Prevalence of Diamine Oxidase Gene Variants in Patients with Symptoms of Histamine Intolerance.Nutrients · 2024Article
- Article
- Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management.Journal of clinical medicine · 2023Article
- Is DAO in serum affected by food challenge with a histamine-rich meal?The journal of allergy and clinical immunology. Global · 2023Article
- Diamine Oxidase Activity Deficit and Idiopathic Rhinitis: A New Subgroup of Non-Allergic Rhinitis?Life (Basel, Switzerland) · 2023Article
- Molecular Mechanisms of Scombroid Food Poisoning.International journal of molecular sciences · 2023Review
- Effects of glutamine, glutamate, and aspartate on intestinal barrier integrity and amino acid pool of the small intestine in piglets with normal or low energy diet.Frontiers in veterinary science · 2023Article
- Basal Serum Diamine Oxidase Levels as a Biomarker of Histamine Intolerance: A Retrospective Cohort Study.Nutrients · 2022Article
- The Missing Link: A Case of Severe Adverse Reaction to Histamine in Food and Beverages.The American journal of case reports · 2022Article
- Oral administration of live combinedFrontiers in microbiology · 2022Article
- 1-methylhistamine as a potential biomarker of food histamine intolerance. A pilot study.Frontiers in nutrition · 2022Article
- Review
- Histamine Intolerance in Children: A Narrative Review.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHistamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls.
methodsWe determined day profiles of histamine plasma levels and DAO serum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food allergy and in 10 healthy control patients. Clinical symptoms, food intolerances and further clinical and laboratory chemical parameters were evaluated.
resultsTwenty-four percent (8 of 33) suspected histamine-intolerant patients showed elevated histamine levels during the day. That might be caused by constantly and significantly reduced DAO activities in these patients compared to food-allergic and control patients. The remaining 25 patients presented normal histamine levels and DAO activities, but an increased prevalence of multiple food intolerances compared to the other subgroup of suspected histamine-intolerants. There was no correlation between subjective complaints and serological histamine parameters in patients with suspected histamine intolerance.
conclusionsWe determined by daily profiling that decreased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine-intolerants. This finding discriminates these patients from food intolerant individuals with similar clinical symptoms and strongly suggests the presence of histamine intolerance.
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