ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04110548 (Emotion and Craving Regulation Among Individuals With Internet Gaming Disorder), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Emotion and Craving Regulation Among Individuals With Internet Gaming Disorder: Cognitive Appraisal and Mindfulness Capacities
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder.Journal of psychiatry & neuroscience : JPN · 2021Trial
- A role for the right dorsolateral prefrontal cortex in enhancing regulation of both craving and negative emotions in internet gaming disorder: A randomized trial.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Trial
- Comorbidity of internet gaming disorder and anxiety in first-year Chinese university students: the mediating role of behavioral inhibition and activation systems.BMC psychiatry · 2025Article
- Altered dynamic reconfiguration of brain functional networks during gaming and deprivation in individuals with internet gaming disorder.Journal of behavioral addictions · 2025Article
- Validation of the Farsi version of the video-game addiction scale for children: its associations with social media addiction, internet addiction and executive functions.BMC psychology · 2025Article
- Gaming disorder: Neural mechanisms and ongoing debates.Journal of behavioral addictions · 2025Review
- Major Depression in Comorbidity with Substance use Disorders: Patients' Features and Clinical-Neurobiological Rationale of Antidepressant Treatments.Current neuropharmacology · 2025Review
- Reduced loss aversion in value-based decision-making and edge-centric functional connectivity in patients with internet gaming disorder.Journal of behavioral addictions · 2023Article
- Altered neural associations with cognitive and emotional functions in cannabis dependence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Independent component analysis for internet gaming disorder.Dialogues in clinical neuroscience · 2023Review
- Psychometric properties of the Farsi version of the gaming disorder scale for adolescents (GADIS-A).BMC psychology · 2022Article
- Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence.Frontiers in psychiatry · 2022Article
- The Clinical Consistency and Utility of ICD-11 Diagnostic Guidelines for Gaming Disorder: A Field Study Among the Chinese Population.Frontiers in psychiatry · 2021Article
- Neurobiological mechanisms underlying internet gaming disorder .Dialogues in clinical neuroscience · 2020Review
- Decreased effective connection from the parahippocampal gyrus to the prefrontal cortex in Internet gaming disorder: A MVPA and spDCM study.Journal of behavioral addictions · 2020Article
- Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder.NeuroImage. Clinical · 2020Article
- Impaired Learning From Errors and Punishments and Maladaptive Avoidance-General Mechanisms Underlying Self-Regulation Disorders?Frontiers in psychiatry · 2020Article
- Emotion Processing, Reappraisal, and Craving in Alcohol Dependence: A Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Difficulties in emotion regulation are commonly reported among individuals with alcohol and drug addictions and contribute to the acquisition and maintenance of addictive behaviors. Alterations in neural processing of negative affective stimuli have further been demonstrated among individuals with addictions. However, it is unclear whether these alterations are a general feature of addictions or are a result of prolonged exposure to drugs of abuse. To test the hypothesis of altered negative affect processing independent of drug effects, this study assessed neural function among drug-naïve youth with a behavioral addiction-Internet gaming disorder (IGD). Fifty-six young adults (28 with IGD, 28 matched controls) participated in fMRI scanning during performance of a well-validated emotion regulation task. Between-group differences in neural activity during task performance were assessed using a whole-brain, mixed-effects ANOVA with correction for multiple comparisons at currently recommended thresholds (voxel-level p<0.001, pFWE<0.05). Compared to controls, youth with IGD exhibited significantly blunted neural responses within distributed subcortical and cortical regions including the striatum, insula, lateral prefrontal cortex and anterior cingulate in response to negative affective cues, as well as during emotion regulation. Independent component analysis (ICA) further identified between-group differences in engagement of a fronto-cingulo-parietal network, involving decreased engagement in IGD youth relative to controls. Study findings are largely consistent with those from prior neuroimaging studies in substance-use disorders, thus raising the possibility that neural processing of negative affect may be blunted across drug and behavioral addictions independent of acute or chronic drug effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.