Evidence map›Paper›PMID 29154191›Full record

ArticleRedox biology2018

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway.

Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 95 citations in OpenAlex.

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  7. Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
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  17. The Role of Immune Dysfunction in Parkinson's Disease Development.International journal of molecular sciences · 2023
    Review
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  20. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Liyan HouSchool of Public Health, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China.
Xiuqi BaoState Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China.
Caixia ZangState Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China.
Hanyu YangState Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China.
Fuqiang SunSchool of Public Health, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China.
Yuning CheSchool of Public Health, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China.
Xuefei WuDepartment of Physiology, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China.
Shao LiDepartment of Physiology, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China.
Dan ZhangState Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China.
Qingshan WangSchool of Public Health, Dalian Medical University, No. 9W. Lvshun South Road, Dalian 116044, China. Electronic address: wangq4@126.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation. In this study, we found that blocking CD11b, the α chain of integrin α

Indexed as

Signal Transductionalpha-SynucleinAnimalsCD11b AntigenCells, CulturedHumansInflammationMaleMiceMice, Inbred C57BLMicrogliaNADPH Oxidase 2rhoA GTP-Binding Proteinrho GTP-Binding Proteinsalpha-SynucleinCD11b AntigenCybb protein, mouseNADPH Oxidase 2rhoA GTP-Binding ProteinRhoA protein, mouserho GTP-Binding ProteinsCD11bIntegrin α(M)β(2)NADPH oxidaseSynucleinopathyα-Synuclein

Identifiers

PMID29154191
PMCPMC5975218
OpenAlexW2767563688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.