Evidence map›Paper›PMID 29154130›Full record

ArticleNeuron2017

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons.

Qiang Wang, Shu-Ling Chiu, Eleftheria Koropouli, Ingie Hong, Sarah Mitchell, Teresa P Easwaran, Natalie R Hamilton, Ahleah S Gustina, Qianwen Zhu, David D Ginty and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
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  6. Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  11. Review
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  14. Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Qiang WangHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shu-Ling ChiuThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Eleftheria KoropouliHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ingie HongThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sarah MitchellHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Teresa P EaswaranHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Natalie R HamiltonHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ahleah S GustinaThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Qianwen ZhuThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David D GintyDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Richard L HuganirThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Alex L KolodkinHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: kolodkin@jhmi.edu.
Johns Hopkins Medicine · USHoward Hughes Medical Institute · USJohns Hopkins University · US

Funding

Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Semaphorin Signaling and Plasticity at the Excitatory SynapseP50MH100024 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2013 to 2017
$9.5M
PDZ DOMAINS AND EXCITATORY SYNAPTIC FUNCTIONR01NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1997 to 2020
$8.6M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
The Dynamic AMPA Receptor Interactome During Plasticity and LearningR37NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Richard L Huganir · 2022 to 2026
$3.2M
Howard Hughes Medical InstituteNIMH NIH HHS P50 MH100024NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS036715NINDS NIH HHS R35 NS097344NINDS NIH HHS R37 NS036715NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity.

Indexed as

AnimalsBicucullineCerebral CortexFemaleGABA AntagonistsHomeostasisMaleMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsNeuronal PlasticityNeuronsNeuropilin-2Primary Cell CultureRats, Sprague-DawleyBicucullineGABA AntagonistsMembrane ProteinsNerve Tissue ProteinsNeuropilin-2Receptors, AMPASema3f protein, mouseAMPA receptorhomeostatic plasticityNeuropilin-2Plexin receptorSema3Fsemaphorin

Identifiers

PMID29154130
PMCPMC5726806
OpenAlexW2768428249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.