ArticleNeuron2017
Lateral Orbitofrontal Inactivation Dissociates Devaluation-Sensitive Behavior and Economic Choice.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Interactions between human orbitofrontal cortex and hippocampus support model-based inference.PLoS biology · 2020Trial
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Striatal dopamine signals errors in prediction across different informational domains.Science advances · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Article
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors.Neurobiology of learning and memory · 2023Review
- Orbitofrontal cortex control of striatum leads economic decision-making.Nature neuroscience · 2023Article
- Preferences reveal separable valuation systems in prefrontal-limbic circuits.bioRxiv : the preprint server for biology · 2023Article
- Computationally Informed Interventions for Targeting Compulsive Behaviors.Biological psychiatry · 2023Review
- The role of the lateral orbitofrontal cortex in creating cognitive maps.Nature neuroscience · 2023Article
- Article
- The whole prefrontal cortex is premotor cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
How do we choose between goods that have different subjective values, like apples and oranges? Neuroeconomics proposes that this is done by reducing complex goods to a single unitary value to allow comparison. This value is computed "on the fly" from the underlying model of the goods space, allowing decisions to meet current needs. This is termed "model-based" behavior to distinguish it from pre-determined, habitual, or "model-free" behavior. The lateral orbitofrontal cortex (OFC) supports model-based behavior in rats and primates, but whether the OFC is necessary for economic choice is less clear. Here we tested this question by optogenetically inactivating the lateral OFC in rats in a classic model-based task and during economic choice. Contrary to predictions, inactivation disrupted model-based behavior without affecting economic choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.