Evidence map›Paper›PMID 29153989›Full record

ArticleStem cell reports2017

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

Minna Oksanen, Andrew J Petersen, Nikolay Naumenko, Katja Puttonen, Šárka Lehtonen, Max Gubert Olivé, Anastasia Shakirzyanova, Stina Leskelä, Timo Sarajärvi, Matti Viitanen and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 2 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 2 syntheses or guidelines pooled it, 336 citations in OpenAlex.

  1. Pooled it
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  9. Reprogramming of neuronal genome function and phenotype by astrocytes.bioRxiv : the preprint server for biology · 2026
    Article
  10. Biochemistry and biophysics reports · 2026
    Review
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  15. Lactate and cognition: a dual modulator.Frontiers in molecular neuroscience · 2026
    Review
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  20. Article

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Minna OksanenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Andrew J PetersenWaisman Center, University of Wisconsin, Madison, WI 53705, USA.
Nikolay NaumenkoA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Katja PuttonenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Šárka LehtonenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Max Gubert OlivéA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Anastasia ShakirzyanovaA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Stina LeskeläA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Timo SarajärviInstitute of Biomedicine, University of Eastern Finland, 70210 Kuopio, Finland.
Matti ViitanenDepartment of Geriatrics, University of Turku, Turku City Hospital, 20700 Turku, Finland; Department of Geriatrics, Karolinska Institutet and Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden.
Juha O RinneTurku PET Centre, University of Turku, 20700 Turku, Finland; Division of Clinical Neurosciences, Turku University Hospital, 20700 Turku, Finland.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, 70210 Kuopio, Finland; Department of Neurology, Kuopio University Hospital, 70210 Kuopio, Finland.
Annakaisa HaapasaloA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Rashid GiniatullinA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Pasi TaviA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Su-Chun ZhangWaisman Center, University of Wisconsin, Madison, WI 53705, USA; Departments of Neuroscience and Neurology, University of Wisconsin, Madison, WI 53705, USA.
Katja M KanninenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Riikka H HämäläinenA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Jari KoistinahoA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland. Electronic address: jari.koistinaho@uef.fi.
University of Eastern Finland · FIUniversity of Wisconsin–Madison · USKarolinska Institutet · SEUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most studies have focused on neuronal cells, but astrocytes have also been suggested to contribute to AD pathology. We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 ΔE9 mutation, as well as healthy and gene-corrected isogenic controls. AD astrocytes manifest hallmarks of disease pathology, including increased β-amyloid production, altered cytokine release, and dysregulated Ca

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAstrocytesBrainCalciumGene Expression RegulationHumansInduced Pluripotent Stem CellsLactic AcidMitochondriaNeuronsOxidative StressPresenilin-1Amyloid beta-PeptidesCalciumLactic AcidPresenilin-1PSEN1 protein, humancalcium homeostasiscytokine releaselactate secretionmitochondrial metabolismoxidative stressβ-amyloid production

Identifiers

PMID29153989
PMCPMC5785689
OpenAlexW2768957663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.