Evidence map›Paper›PMID 29153783›Full record

ArticleGeneral hospital psychiatry

Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy.

Shannon M Nugent, Bobbi Jo Yarborough, Ning X Smith, Steven K Dobscha, Richard A Deyo, Carla A Green, Benjamin J Morasco

Abstract readComparative Study
In one paragraph

Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shannon M NugentCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, United States; Mental Health and Clinical Neurosciences Division, VA Portland Health Care System, United States; Department of Psychiatry, Oregon Health & Science University, United States. Electronic address: Shannon.nugent@va.gov.
Bobbi Jo YarboroughKaiser Permanente Northwest Center for Health Research, United States.
Ning X SmithKaiser Permanente Northwest Center for Health Research, United States.
Steven K DobschaCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, United States; Mental Health and Clinical Neurosciences Division, VA Portland Health Care System, United States; Department of Psychiatry, Oregon Health & Science University, United States.
Richard A DeyoKaiser Permanente Northwest Center for Health Research, United States; Departments of Family Medicine, Internal Medicine, Oregon Institute for Occupational Health Sciences, Oregon Health & Science University, United States; Public Health and Preventive Medicine, Oregon Health & Science University, United States.
Carla A GreenKaiser Permanente Northwest Center for Health Research, United States; Public Health and Preventive Medicine, Oregon Health & Science University, United States.
Benjamin J MorascoCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, United States; Mental Health and Clinical Neurosciences Division, VA Portland Health Care System, United States; Department of Psychiatry, Oregon Health & Science University, United States.

Funding

Correlates and outcomes of opioid dose escalation among chronic pain patientsR01DA034083 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORASCO, BENJAMIN J. · 2013 to 2017
$2.4M
NIDA NIH HHS R01 DA034083
6 · The paper itself

Abstract

objectiveLittle is known about co-occurring long-term opioid therapy (LTOT) and medical cannabis use. We compared characteristics of patients prescribed LTOT who endorsed using medical cannabis for pain to patients who did not report cannabis use.

methodParticipants (n=371) prescribed LTOT completed self-report measures about pain, substance use, and mental health.

resultsEighteen percent of participants endorsed using medical cannabis for pain. No significant differences were detected on pain-related variables, depression, or anxiety between those who endorsed medical cannabis use and those who did not. Medical cannabis users had higher scores of risk for prescription opioid misuse (median=17.0 vs. 11.5, p<0.001), rates of hazardous alcohol use (25% vs. 16%, p<0.05), and rates of nicotine use (42% vs. 26%, p=0.01). Multivariable analyses indicated that medical cannabis use was significantly associated with risk of prescription opioid misuse (β=0.17, p=0.001), but not hazardous alcohol use (aOR=1.96, 95% CI=0.96-4.00, p=0.06) or nicotine use (aOR=1.61, 95% CI=0.90-2.88, p=0.11).

conclusionThere are potential risks associated with co-occurring LTOT and medical cannabis for pain. Study findings highlight the need for further clinical evaluation in this population. Future research is needed to examine the longitudinal impact of medical cannabis use on pain-related and substance use outcomes.

Indexed as

AdultAgedAnalgesics, OpioidFemaleHumansMaleMedical MarijuanaMiddle AgedMusculoskeletal PainPain ManagementPrescription Drug MisuseAnalgesics, OpioidMedical MarijuanaChronic painLong-term-opioid therapyMedical cannabisPrescription opioid misuse

Identifiers

PMID29153783
PMCPMC5788035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.