ArticleFertility and sterility2018
Ambient air pollution and the risk of pregnancy loss: a prospective cohort study.
Article in Fertility and sterility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Gestational age modifies the association between exposure to fine particles and fetal death: findings from a nationwide epidemiological study in the contiguous United States.Environmental health : a global access science source · 2023Pooled it
- The relationship between air pollutants and gestational diabetes: an updated systematic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- Effects of a LPG stove and fuel intervention on adverse maternal outcomes: A multi-country randomized controlled trial conducted by the Household Air Pollution Intervention Network (HAPIN).Environment international · 2023Trial
- Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes.Paediatric and perinatal epidemiology · 2026Article
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers.iScience · 2026Article
- Impact of climate change on spontaneous abortion: a systematic review and meta-analysis.Frontiers in global women's health · 2026Review
- Associations of mixed exposure to ambient air pollution and environmental factors with the risk of miscarriage in women undergoing assisted reproductive technology: a retrospective cohort study.BMC public health · 2025Article
- Association of fine particulate matter exposure during pregnancy and stillbirth rates in Pakistan: a cross-sectional study.BMJ open · 2025Article
- Ambient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort.Environmental research · 2025Article
- Associations of climatic factors with pregnancy loss in Nicosia, Cyprus.Journal of exposure science & environmental epidemiology · 2025Article
- Review
- Estradiol trajectories and early pregnancy loss: a retrospective study.Frontiers in endocrinology · 2025Article
- Diagnosis and management of early pregnancy loss.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Review
- Prenatal exposure to air pollutant mixtures and birthweight in the upstate KIDS cohort.Environment international · 2024Article
- Ambient air pollution and rate of spontaneous abortion.Environmental research · 2024Article
- Understanding trimester-specific miscarriage risk in Indian women: insights from the calendar data of National Family Health Survey (NFHS-5) 2019-21.BMC women's health · 2024Article
- Maternal health outcomes in the context of fragility: a retrospective study from Lebanon.Conflict and health · 2023Article
- A Retrospective Observational Study Using Administrative Databases to Assess the Risk of Spontaneous Abortions Related to Environmental and Socioeconomic Conditions.Life (Basel, Switzerland) · 2023Article
- Preconceptional and prenatal exposure to air pollutants and risk of gestational diabetes in the MADRES prospective pregnancy cohort study.Lancet regional health. Americas · 2023Article
- Environmental Exposure: Effect on Maternal Morbidity and Mortality and Neonatal Health.Cureus · 2023Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo estimate the association of pregnancy loss with common air pollutant exposure. Ambient air pollution exposure has been linked to adverse pregnancy outcomes, but few studies have investigated its relationship with pregnancy loss.
designProspective cohort study.
settingNot applicable. PATIENT(S): A total of 343 singleton pregnancies in a multisite prospective cohort study with detailed protocols for ovulation and pregnancy testing. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Timing of incident pregnancy loss (from ovulation). RESULT(S): The incidence of pregnancy loss was 28% (n = 98). Pollutant levels at women's residences were estimated using modified Community Multiscale Air Quality models and averaged during the past 2 weeks (acute) and the whole pregnancy (chronic). Adjusted Cox proportional hazards models showed that an interquartile range increase in average whole pregnancy ozone (hazard ratio [HR] 1.12, 95% confidence interval [CI] 1.07-1.17) and particulate matter <2.5 μm (HR 1.13, 95% CI 1.03-1.24) concentrations were associated with faster time to pregnancy loss. Sulfate compounds also appeared to increase risk (HR 1.58, 95% CI 1.07-2.34). Last 2 weeks of exposures were not associated with loss. CONCLUSION(S): In a prospective cohort of couples trying to conceive, we found evidence that exposure to air pollution throughout pregnancy was associated with loss, but delineating specific periods of heightened vulnerability await larger preconception cohort studies with daily measured air quality.
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