Evidence map›Paper›PMID 29153674›Full record

ArticlePregnancy hypertension2017

Labor therapeutics and BMI as risk factors for postpartum preeclampsia: A case-control study.

Geraldine Skurnik, Shelley Hurwitz, Thomas F McElrath, Lawrence C Tsen, Stacey Duey, Aditi R Saxena, Ananth Karumanchi, Janet W Rich-Edwards, Ellen W Seely

Open access · greenAbstract read
In one paragraph

Article in Pregnancy hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Geraldine SkurnikDivision of Endocrine, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: gskurnik@partners.org.
Shelley HurwitzDivision of Endocrine, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Thomas F McElrathDivision of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Lawrence C TsenDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Stacey DueyResearch Patient Data Registry/Biobank Portal, Brigham and Women's Hospital, Boston, MA, United States.
Aditi R SaxenaDivision of Endocrine, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Ananth KarumanchiDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Janet W Rich-EdwardsConnors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Ellen W SeelyDivision of Endocrine, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Harvard University · USBrigham and Women's Hospital · US

Funding

TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Salt Sensitive Hypertension and StriatinR01HL144779 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 2019 to 2022
$3.3M
Unique cardiovascular Risk Factors in Women Research and Mentoring ProgamK24HL096141 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SEELY, ELLEN W · 2010 to 2014
$997k
NHLBI NIH HHS K24 HL096141NHLBI NIH HHS R01 HL144779NHLBI NIH HHS T32 HL007609NICHD NIH HHS K12 HD051959
6 · The paper itself

Abstract

objectivesThis study aims at identifying associations between therapeutics used during labor and the occurrence of postpartum preeclampsia (PPPE), a poorly understood entity. STUDY DESIGN AND

main outcome measuresThis is a case-control study of women who received an ICD-9 code for PPPE (cases) during the years 2009-2011, compared to women with a normotensive term pregnancy, delivery and postpartum period until discharge (controls), matched on age (±1year) and delivery date (±3months). Cases were defined as women having a normotensive term pregnancy, delivery and initial postpartum period (48h post-delivery) but developing hypertension between 48h and 6weeks postpartum. Single variable and multiple variable models were used to determine significant risk factors.

resultsForty-three women with PPPE were compared to 86 controls. Use of vasopressors and oxytocin did not differ between cases and controls, but rate of fluids administered during labor (OR=1.68 per 100cc/h; 95% CI: 1.09-2.59, p=0.02) and an elevated pre-pregnancy/first trimester BMI (OR=1.18 per kg/m

conclusionsWe identified two potentially modifiable risk factors for PPPE; further studies are needed to better define the role of these two variables in the development of PPPE.

Indexed as

AdultBody Mass IndexBostonCase-Control StudiesFemaleFluid TherapyHumansLabor, ObstetricPre-EclampsiaPregnancyPregnancy Trimester, FirstPuerperal DisordersBMIFluidsLabor therapeuticsObesityPostpartum preeclampsia

Identifiers

PMID29153674
PMCPMC5747249
OpenAlexW2737235096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.