Evidence map›Paper›PMID 29153616›Full record

ArticleJournal of neuroimmunology2017

A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress.

Harlan P Jones, Beau Aldridge, Katherine Boss-Williams, Jay M Weiss

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. B cells in tumor metastasis: friend or foe?International journal of biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Harlan P JonesDepartment of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: Harlan.Jones@unthsc.edu.
Beau AldridgeDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Katherine Boss-WilliamsDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Jay M WeissDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · USUniversity of North Texas Health Science Center · US

Funding

Controllability of Stress--Effects on Tumor DevelopmentR01CA087923 · NCI · EMORY UNIVERSITY · PI WEISS, JAY MICHAEL · 2001 to 2004
$1.2M
NCI NIH HHS R01 CA087923
6 · The paper itself

Abstract

Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80

Indexed as

AdenocarcinomaAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorCytokinesElectroshockFemaleGene Expression Regulation, NeoplasticKiller Cells, NaturalLung NeoplasmsLymphocytesNeoplasms, ExperimentalRatsRats, Inbred F344CytokinesRNA, MessengerImmunityLungMetastasisStress

Identifiers

PMID29153616
PMCPMC5707131
OpenAlexW2766012319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.