Evidence map›Paper›PMID 29153393›Full record

ReviewMolecular cell2018

Protein-Based Inheritance: Epigenetics beyond the Chromosome.

Zachary H Harvey, Yiwen Chen, Daniel F Jarosz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 189 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zachary H HarveyDepartment of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA.
Yiwen ChenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA.
Daniel F JaroszDepartment of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA. Electronic address: jarosz@stanford.edu.
Stanford University · US

Funding

Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI SUDHOF, THOMAS C. · 2015 to 2019
$7.9M
Protein-based Molecular Memories in Gene Regulation, Disease, and DevelopmentDP2GM119140 · NIGMS · STANFORD UNIVERSITY · PI JAROSZ, DANIEL · 2015 to 2015
$2.4M
Molecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1M
NIA NIH HHS P50 AG047366NIGMS NIH HHS DP2 GM119140NIGMS NIH HHS T32 GM113854
6 · The paper itself

Abstract

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. This phenomenon has largely been studied in the context of chromatin modification. Yet many epigenetic traits are instead linked to self-perpetuating changes in the individual or collective activity of proteins. Most such proteins are prions (e.g., [PSI

Indexed as

AnimalsEpigenesis, GeneticEpigenomicsHeredityHumansMeiosisMitosisPhenotypePrionsProteinsPrionsProteinsepigenetic inheritanceprions

Identifiers

PMID29153393
PMCPMC5775936
OpenAlexW2769292253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.