Evidence map›Paper›PMID 29153131›Full record

ArticleKidney international2017

Donor SIRP-α polymorphisms: widening the innate-to-adaptive continuum in allograft rejection.

Madhav C Menon, Peter S Heeger

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Innate allorecognition in transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Madhav C MenonTranslational Transplant Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: madhav.menon@mssm.edu.
Peter S HeegerTranslational Transplant Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the usual paradigm, self:nonself recognition is attributed to calls of the adaptive immune system, owing to variations in specialized genes encoded within the major histocompatibility complex loci. However, an increasing body of data has shown that cells of the innate immune system also have self:nonself recognition functions relevant to organ transplantation, and this trait may derive from genes located outside the major histocompatibility complex loci. A recent publication identifies the donor SIRP-α gene as a non-major histocompatibility complex locus responsible for nonself recognition by monocytes, with variability resulting in changes in the surface interaction of SIRP-α with its ligand CD47.

Indexed as

acute rejectiongene expression

Identifiers

PMID29153131
OpenAlexW2768223947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.