ArticleJournal of applied clinical medical physics2018
On the gEUD biological optimization objective for organs at risk in Photon Optimizer of Eclipse treatment planning system.
Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Volumetric Modulated Arc Therapy Versus Dynamic Conformal Arc Therapy for Single Isocenter Stereotactic Radiotherapy of Multiple Brain Metastases.Bioengineering (Basel, Switzerland) · 2026Article
- Fully automated intensity-modulated radiotherapy plans for rectal cancer based on deep learning predictions of three-dimensional dose distributions.Quantitative imaging in medicine and surgery · 2025Article
- Impact of monitor unit optimization in volumetric modulated arc therapy planning for nasopharyngeal carcinoma.PloS one · 2025Article
- Selective sparing of bladder and rectum sub-regions in radiotherapy of prostate cancer combining knowledge-based automatic planning and multicriteria optimization.Physics and imaging in radiation oncology · 2023Article
- Including Volume Effects in Biological Treatment Plan Optimization for Carbon Ion Therapy: Generalized Equivalent Uniform Dose-Based Objective in TRiP98.Frontiers in oncology · 2022Article
- Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator.The British journal of radiology · 2021Article
- Dosimetric Comparison, Treatment Efficiency Estimation, and Biological Evaluation of Popular Stereotactic Radiosurgery Options in Treating Single Small Brain Metastasis.Frontiers in oncology · 2021Article
- Automating proton treatment planning with beam angle selection using Bayesian optimization.Medical physics · 2020Article
- Study on the ability of 3D gamma analysis and bio-mathematical model in detecting dose changes caused by dose-calculation-grid-size (DCGS).Radiation oncology (London, England) · 2020Article
- Using biologically based objectives to optimize boost intensity-modulated radiation therapy planning for brainstem tumors in dogs.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2020Article
- Critical Appraisal of the Treatment Planning Performance of Volumetric Modulated Arc Therapy by Means of a Dual Layer Stacked Multileaf Collimator for Head and Neck, Breast, and Prostate.Technology in cancer research & treatment · 2018Article
- Paradigm Shift in Radiation Treatment Planning Over Multiple Treatment Modalities.Journal of medical physicsReview
- A Model-Based Method for Assessment of Salivary Gland and Planning Target Volume Dosimetry in Volumetric-Modulated Arc Therapy Planning on Head-and-Neck Cancer.Journal of medical physicsArticle
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6 authors.
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Abstract
Inverse planning optimization using biologically based objectives is becoming part of the intensity modulated optimization process. The performances and efficacy of the biologically based gEUD (generalized Equivalent Uniform Dose) objective implemented in the Photon Optimizer (PO) of Varian Eclipse treatment planning system have been here analyzed. gEUD is associated with the parameter a that accounts for the seriality of a structure, being higher for more serial organs. The PO was used to optimize volumetric modulated arc therapy (VMAT) plans on a virtual homogeneous cylindrical phantom presenting a target and an organ at risk (OAR). The OAR was placed at 4 mm, 1 and 2 cm distance, or cropped at 0, 2 and 4 mm from the target. Homogeneous target dose of 60 Gy in 20 fractions was requested with physical dose-volume objectives, while OAR dose was minimized with the upper gEUD objective. The gEUD specific a parameter was varied from 0.1 to 40 to assess its impact to OAR sparing and target coverage. Actual head and neck and prostate cases, with one parotid and the rectum as test OAR, were also analyzed to translate the results in the more complex clinical environment. Increasing the a parameter value in the gEUD objective, the optimization achieved lower volumes of the OAR which received the highest dose levels. The maximum dose in the OAR was minimized well with a values up to 20, while further increase of a to 40 did not further improve the result. The OAR mean dose was reduced for the OAR located at 1 and 2 cm distance from the target, enforced with increasing a. For cropped OARs, a mean dose reduction was achieved for a values up to 3-5, but mean dose increased for higher a values. The optimal choice of the parameter a depends on the mutual OAR and target position, and seriality of the organ. Today no significant compendium of clinical and biological specific a and gEUD values are available for a wide range of OARs.
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