ArticleEnvironmental disease
A novel approach to analyzing lung cancer mortality disparities: Using the exposome and a graph-theoretical toolchain.
Article in Environmental disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The need for a cancer exposome atlas: a scoping review.JNCI cancer spectrum · 2025Article
- Understanding exposomes and its relation with cancer risk in Malaysia based on epidemiological evidence: a narrative review.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024Review
- Seminar: Scalable Preprocessing Tools for Exposomic Data Analysis.Environmental health perspectives · 2023Article
- Community-level exposomics: a population-centered approach to address public health concerns.Exposome · 2023Article
- Exposome approach for identifying modifiable factors for the prevention of colorectal cancer.Scientific reports · 2022Article
- Rethinking of Environmental Health Risks: A Systematic Approach of Physical-Social Health Vulnerability Assessment on Heavy-Metal Exposure through Soil and Vegetables.International journal of environmental research and public health · 2021Article
- Unsupervised dimensionality reduction for exposome research.Current opinion in environmental science & health · 2020Article
- The Chemical Exposome of Human Aging.Frontiers in genetics · 2020Review
- Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions.Toxics · 2019Review
- Application of the Public Health Exposome Framework to Estimate Phenotypes of Resilience in a Model Ohio African-American Women's Cohort.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Article
- Lung cancer health disparities.Carcinogenesis · 2018Review
- Applying an Exposome-Wide (ExWAS) Approach to Cancer Research.Frontiers in oncology · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesThe aim is to identify exposures associated with lung cancer mortality and mortality disparities by race and gender using an exposome database coupled to a graph theoretical toolchain.
methodsGraph theoretical algorithms were employed to extract paracliques from correlation graphs using associations between 2162 environmental exposures and lung cancer mortality rates in 2067 counties, with clique doubling applied to compute an absolute threshold of significance. Factor analysis and multiple linear regressions then were used to analyze differences in exposures associated with lung cancer mortality and mortality disparities by race and gender.
resultsWhile cigarette consumption was highly correlated with rates of lung cancer mortality for both white men and women, previously unidentified novel exposures were more closely associated with lung cancer mortality and mortality disparities for blacks, particularly black women.
conclusionsExposures beyond smoking moderate lung cancer mortality and mortality disparities by race and gender. POLICY IMPLICATIONS: An exposome approach and database coupled with scalable combinatorial analytics provides a powerful new approach for analyzing relationships between multiple environmental exposures, pathways and health outcomes. An assessment of multiple exposures is needed to appropriately translate research findings into environmental public health practice and policy.
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Identifiers
29152601PMC5687093What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.