ArticlemSystems
A Synthetic Community System for Probing Microbial Interactions Driven by Exometabolites.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- It takes a village: how plant-associated bacterial communities socialise to shape plant growth and health.Essays in biochemistry · 2026Review
- Synthetic microbial communities for studying the fate and ecological role of specialized metabolites.Essays in biochemistry · 2026Review
- When context matters: community and environmental context to elicit natural products.Essays in biochemistry · 2026Review
- Multi-omic characterization of a soil microbial consortium reveals critical role of succinate and glutamate metabolism during calcium carbonate precipitation.BMC biotechnology · 2026Article
- Integrating metagenome-scale metabolic models and metabolomics to explore candidate biochemical interactions in cultivatedISME communications · 2026Article
- Interactions between native soil microbiome and a synthetic microbial community reveals bacteria with persistent traits.mSystems · 2025Article
- Advances in synthetic microbial ecosystems approach for studying ecological interactions and their influencing factors.Engineering microbiology · 2025Review
- Roles of microbial interactions in determining the establishment and function of synthetic consortium inoculants for soil applications.The ISME journal · 2025Article
- A stable 15-member bacterial SynCom promotesFrontiers in microbiology · 2025Article
- Bioactive exometabolites drive maintenance competition in simple bacterial communities.mSystems · 2024Article
- Opportunities in optical and electrical single-cell technologies to study microbial ecosystems.Frontiers in microbiology · 2023Review
- THOR's Hammer: the Antibiotic Koreenceine Drives Gene Expression in a Model Microbial Community.mBio · 2022Article
- Computational Analysis of Microbial Flow Cytometry Data.mSystems · 2021Review
- Formation, characterization and modeling of emergent synthetic microbial communities.Computational and structural biotechnology journal · 2021Article
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- Fitness and Productivity Increase with Ecotypic Diversity amongApplied and environmental microbiology · 2020Article
- Coculturing Bacteria Leads to Reduced Phenotypic Heterogeneities.Applied and environmental microbiology · 2019Article
- Biphasic cellular adaptations and ecological implications of Alteromonas macleodii degrading a mixture of algal polysaccharides.The ISME journal · 2019Article
- Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance.Communications biology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though most microorganisms live within a community, we have modest knowledge about microbial interactions and their implications for community properties and ecosystem functions. To advance understanding of microbial interactions, we describe a straightforward synthetic community system that can be used to interrogate exometabolite interactions among microorganisms. The filter plate system (also known as the Transwell system) physically separates microbial populations, but allows for chemical interactions via a shared medium reservoir. Exometabolites, including small molecules, extracellular enzymes, and antibiotics, are assayed from the reservoir using sensitive mass spectrometry. Community member outcomes, such as growth, productivity, and gene regulation, can be determined using flow cytometry, biomass measurements, and transcript analyses, respectively. The synthetic community design allows for determination of the consequences of microbiome diversity for emergent community properties and for functional changes over time or after perturbation. Because it is versatile, scalable, and accessible, this synthetic community system has the potential to practically advance knowledge of microbial interactions that occur within both natural and artificial communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.