Evidence map›Paper›PMID 29152584›Full record

ArticlemSystems

Large-Scale Bioinformatics Analysis of

Kirk J Grubbs, Rachel M Bleich, Kevin C Santa Maria, Scott E Allen, Sherif Farag, AgBiome Team, Elizabeth A Shank, Albert A Bowers

Open access · goldAbstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 107 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Draft genome ofMicrobiology resource announcements · 2024
    Article
  10. Genomic Characterization ofMicroorganisms · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Frontiers in plant science · 2024
    Review
  15. Article
  16. The Extracellular Lipopeptides and Volatile Organic Compounds ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  17. Characterization of a NovelMicroorganisms · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kirk J GrubbsDepartment of Biology, University of North Carolina, Chapel Hill, North Carolina, USA.
Rachel M BleichEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
Kevin C Santa MariaDepartment of Chemistry, University of North Carolina, Chapel Hill, North Carolina, USA.
Scott E AllenEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
Sherif FaragEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
AgBiome Team
Elizabeth A ShankDepartment of Biology, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-4804-1966
Albert A BowersEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · US

Funding

Using Co-culture and Bioinformatics to Discover New Antibiotic BioactivitiesR01GM112981 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHANK, ELIZABETH ANNE · 2016 to 2020
$1.4M
NIGMS NIH HHS R01 GM112981
6 · The paper itself

Abstract

Bacteria possess an amazing capacity to synthesize a diverse range of structurally complex, bioactive natural products known as specialized (or secondary) metabolites. Many of these specialized metabolites are used as clinical therapeutics, while others have important ecological roles in microbial communities. The biosynthetic gene clusters (BGCs) that generate these metabolites can be identified in bacterial genome sequences using their highly conserved genetic features. We analyzed an unprecedented 1,566 bacterial genomes from

Indexed as

Bacillusbioinformaticsnatural productsnonribosomal peptide synthetasepolyketidessecondary metabolismspecialized metabolitessporulationthiopeptides

Identifiers

PMID29152584
PMCPMC5686519
OpenAlexW2768940136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.