Evidence map›Paper›PMID 29151984›Full record

ArticleThe open biochemistry journal2017

Hepatic and Aortic Arch Expression and Serum Levels of Syndecan-1 in ApoE

Elena I Leonova, Elena S Sadovnikova, Elvira R Shaykhutdinova, Oxana V Galzitskaya, Arkady N Murashev, Alexandr S Solonin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The open biochemistry journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Elena I LeonovaInstitute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Moscow Region, Pushchino, 142290, Russia.
Elena S SadovnikovaBranch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.
Elvira R ShaykhutdinovaBranch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.
Oxana V GalzitskayaInstitute of Protein Research, Russian Academy of Sciences, Moscow Region, Pushchino, Russia.
Arkady N MurashevBranch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.
Alexandr S SoloninInstitute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Moscow Region, Pushchino, 142290, Russia.
Institute of Bioorganic Chemistry · RUG. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms · RUInstitute of Protein Research · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeparan sulfate proteoglycan (HSPG) syndecan-1 (Sdc1) acts as a receptor for triglyceride-rich lipoproteins (TRLs), growth factors, chemokines and enzymes. Due to the disordered structure, its function is as diverse as its ligands. In this paper, we have analyzed hepatic and aortic arch expression of Sdc1 in ApoE

methodsApoE knockout (ApoE

resultsThe Sdc1 mRNA level in liver cells was 1.5-2.5 times higher in ApoE

conclusionOur data suggest that the level of soluble Sdc1 in serum of mice can be associated with chronic inflammation. In addition, we hypothesized that a compensatory increase in the Sdc1 expression in ApoE

Indexed as

ApoE-/- miceC57Black miceCholesterol levelDisordered structureHSPGSyndecan-1

Identifiers

PMID29151984
PMCPMC5676011
OpenAlexW2733316887

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.