ArticleEvolutionary applications2017
A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America.
Article in Evolutionary applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Genome-wide analyses of an avian herpesvirus identify 10 loci associated with tumorigenicity and vaccine escape.Science advances · 2026Article
- Virulence of Marek's disease virus in Japan is linked to polymorphisms in theThe Journal of general virology · 2026Article
- Pathogenicity analysis and control strategies to combat avian diseases: mechanisms of increased virulence of Marek's disease virus and the development of vaccines against poultry red mites.The Journal of veterinary medical science · 2025Review
- Two distinct polymorphisms in the basic region of Meq protein of marek's disease virus alter pathological progression and clinical manifestations.Virology journal · 2025Article
- The Role of Artificial Intelligence in Herpesvirus Detection, Transmission, and Predictive Modeling: With a Special Focus on Marek's Disease Virus.Pathogens (Basel, Switzerland) · 2025Review
- High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions.PLoS pathogens · 2025Article
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- Genomic characteristics and distinctive genetic polymorphisms of Marek's disease virus strains circulating in Japan.The Journal of veterinary medical science · 2025Article
- Surveillance and Molecular Characterization of Marek's Disease Virus (MDV) Strains Circulating in Tanzania.Viruses · 2025Article
- Marek's Disease Virus (MDV) Meq Oncoprotein Plays Distinct Roles in Tumor Incidence, Distribution, and Size.Viruses · 2025Article
- Marek's disease: A global challenge to poultry health and productivity.Open veterinary journal · 2025Review
- TheViruses · 2024Article
- Molecular characterization of theThe veterinary quarterly · 2024Article
- Virulence evaluation of Israeli Marek's disease virus isolates from commercial poultry using their meq gene sequence.Virus genes · 2024Article
- Characterization of a Very Short Meq Protein Isoform in a Marek's Disease Virus Strain in Japan.Veterinary sciences · 2024Article
- First Report of Marek's Disease Virus in Commercial Turkeys in Slovenia.Animals : an open access journal from MDPI · 2024Article
- Comparative analysis of multiple consensus genomes of the same strain of Marek's disease virus reveals intrastrain variation.Virus evolution · 2024Article
- The First Record of an Aggressive Form of Ocular Tumour Enhanced by Marek's Disease Virus Infection in Layer Flock in Al-Najaf, Iraq.Veterinary medicine international · 2024Article
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9 authors.
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Abstract
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus (MDV), a herpesvirus commonly afflicting chickens and rarely other avian species. The history of MDV in the 20th century represents an important case study in the evolution of virulence. The severity of MDV infection in chickens has been rising steadily since the adoption of intensive farming techniques and vaccination programs in the 1950s and 1970s, respectively. It has remained uncertain, however, which of these factors is causally more responsible for the observed increase in virulence of circulating viruses. We conducted a phylogenomic study to understand the evolution of MDV in the context of dramatic changes to poultry farming and disease control. Our analysis reveals evidence of geographical structuring of MDV strains, with reconstructions supporting the emergence of virulent viruses independently in North America and Eurasia. Of note, the emergence of virulent viruses appears to coincide approximately with the introduction of comprehensive vaccination on both continents. The time-dated phylogeny also indicated that MDV has a mean evolutionary rate of ~1.6 × 10
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