ArticleFood & nutrition research2017
Late introduction of fish and eggs is associated with increased risk of allergy development - results from the FARMFLORA birth cohort.
Article in Food & nutrition research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies.European journal of pediatrics · 2024Pooled it
- Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery.BMC pediatrics · 2025Article
- Drivers and barriers to fish and seafood consumption in the first 1000 days of life.NPJ science of food · 2025Article
- Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy.PloS one · 2024Article
- The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy.Biology · 2023Review
- Review
- Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema.Scientific reports · 2020Article
- Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease.Nutrients · 2020Article
- Nutritional Issues in Food Allergy.Clinical reviews in allergy & immunology · 2019Review
- Appropriate age range for introduction of complementary feeding into an infant's diet.EFSA journal. European Food Safety Authority · 2019Article
- Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study.European journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of allergy is markedly low in children growing up on farms. An increasing number of studies indicate that the timing of food introduction may affect allergy development. We aimed to investigate if protection against allergy in farm environments may be mediated through differences in food-introduction practices between farm and non-farm families, using an explorative approach. Twenty-eight farm and 37 non-farm children were included in the FARMFLORA birth cohort. Practices of breastfeeding and introduction of formulas and complementary foods were collected by questionnaires at 6, 12, and 18 months of age. Allergy was diagnosed by pediatricians at 3 years of age. The only difference in food-introduction practices observed between farm and non-farm children was an earlier introduction of nuts in farmers (median month: 11 [IQR: 8-6] in farmers, 15 [12-19] in non-farmers). One farm child (4%) and 10 non-farm children (27%) were allergic at 3 years of age. Lower risk of allergy development was associated with early exclusive breastfeeding (continuous variable; OR = 0.59, 95% CI: 0.39-0.89), but also having received eggs (OR = 0.08, 95% CI: 0.13-0.54) and fish (logistic regression not applicable,
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