Evidence map›Paper›PMID 29151826›Full record

ArticleAdvanced functional materials2017

Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-guided Photodynamic Cancer Therapy.

Liang Cheng, Dawei Jiang, Anyanee Kamkaew, Hector F Valdovinos, Hyung-Jun Im, Liangzhu Feng, Christopher G England, Shreya Goel, Todd E Barnhart, Zhuang Liu and 1 more

Abstract read
In one paragraph

Article in Advanced functional materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions.Journal of the American Society of Nephrology : JASN · 2025
    Review
  3. Review
  4. Article
  5. pH-Activatable Pre-Nanozyme Mediated HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. A review of advances in the last decade on targeted cancer therapy usingAmerican journal of nuclear medicine and molecular imaging · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Renal clearable nanocarriers: Overcoming the physiological barriers for precise drug delivery and clearance.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Dawei JiangDepartments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.
Anyanee KamkaewDepartments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.
Hector F ValdovinosDepartment of Medical Physics, University of Wisconsin-Madison, Wisconsin 53705, United States.
Hyung-Jun ImDepartments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.
Liangzhu FengInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin-Madison, Wisconsin 53705, United States.
Shreya GoelMaterials Science Program, University of Wisconsin-Madison, Wisconsin 53705, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, Wisconsin 53705, United States.
Zhuang LiuInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Weibo CaiDepartments of Radiology, University of Wisconsin-Madison, Wisconsin 53705, United States.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB021336
6 · The paper itself

Abstract

Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG

Indexed as

Dynamic PET imagingFluorescence imagingPhotodynamic therapyRenal clearanceTCPP-PEG nanoparticles

Identifiers

PMID29151826
PMCPMC5687274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.