Evidence map›Paper›PMID 29151581›Full record

ArticleCellular & molecular immunology2018

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses.

Tomonori Yaguchi, Asuka Kobayashi, Takashi Inozume, Kenji Morii, Haruna Nagumo, Hiroshi Nishio, Takashi Iwata, Yuyo Ka, Ikumi Katano, Ryoji Ito and 2 more

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tomonori YaguchiDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Asuka KobayashiDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Takashi InozumeDepartment of Dermatology, Yamanashi University School of Medicine, Yamanashi 409-3898, Japan.
Kenji MoriiDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Haruna NagumoDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Hiroshi NishioDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Takashi IwataDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan.
Yuyo KaCentral Institute for Experimental Animals, Kanagawa 210-0821, Japan.
Ikumi KatanoCentral Institute for Experimental Animals, Kanagawa 210-0821, Japan.
Ryoji ItoCentral Institute for Experimental Animals, Kanagawa 210-0821, Japan.
Mamoru ItoCentral Institute for Experimental Animals, Kanagawa 210-0821, Japan.
Yutaka KawakamiDivision of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan. yutakawa@keio.jp.
Keio University · JPCentral Institute for Experimental Animals · JPUniversity of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg

Indexed as

Leukocytes, MononuclearModels, ImmunologicalAdoptive TransferAnimalsHeterograftsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansMART-1 AntigenMice, Inbred NODMice, KnockoutMice, SCIDHistocompatibility Antigens Class IHistocompatibility Antigens Class IIMART-1 Antigenadoptive cell therapyhumanized mousevaccine

Identifiers

PMID29151581
PMCPMC6207709
OpenAlexW2770694551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.