Evidence map›Paper›PMID 29151119›Full record

SynthesisPediatric radiology2018

Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review.

A M Smets, E E Deurloo, T J E Slager, J Stoker, S Bipat

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  6. Whole-Body MRI VersusCancers · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

A M SmetsDepartment of Radiology and Nuclear Medicine, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands. a.m.smets@amc.uva.nl.
E E DeurlooDepartment of Radiology and Nuclear Medicine, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
T J E SlagerDepartment of Radiology and Nuclear Medicine, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
J StokerDepartment of Radiology and Nuclear Medicine, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
S BipatDepartment of Radiology and Nuclear Medicine, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
Academic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany solid neoplasms have a propensity for osteomedullary metastases of which detection is important for staging and subsequent treatment. Whole-body magnetic resonance imaging (WB-MRI) has been shown to accurately detect osteomedullary metastases in adults, but these findings cannot be unconditionally extrapolated to staging of children with malignant solid tumors.

objectiveTo conduct a literature review on the sensitivity of WB-MRI for detecting skeletal metastases in children with solid tumors. MATERIALS AND

methodsSearches in MEDLINE and EMBASE databases up to 15 May 2017 were performed to identify studies on the diagnostic value of WB-MRI. Inclusion criteria were children and adolescents (age <21 years) with a primary solid tumor who were evaluated for skeletal metastases by WB-MRI and compared to any type of reference standard. The number of included patients had to be at least five and data on true positives, true negatives, false-positives and false-negatives had to be extractable.

resultsFive studies including 132 patients (96 patients with solid tumors) were eligible. Patient groups and used reference tests were heterogeneous, producing unclear or high risk of bias. Sensitivity of WB-MRI ranged between 82% and 100%. The positive predictive value of WB-MRI was variable among the studies and influenced by the used reference standard.

conclusionAlthough WB-MRI may seem a promising radiation-free technique for the detection of skeletal metastases in children with solid tumors, published studies are small and too heterogeneous to provide conclusive evidence that WB-MRI can be an alternative to currently used imaging techniques.

Indexed as

AdolescentBone NeoplasmsChildHumansMagnetic Resonance ImagingNeoplasm StagingSensitivity and SpecificityWhole Body ImagingAdolescentsBoneCancerChildrenMetastasisSolid tumorsWhole-body magnetic resonance imagingYoung adults

Identifiers

PMID29151119
PMCPMC5790860
OpenAlexW2771016291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.