Evidence map›Paper›PMID 29150884›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2018

Directional local field potentials: A tool to optimize deep brain stimulation.

Gerd Tinkhauser, Alek Pogosyan, Ines Debove, Andreas Nowacki, Syed Ahmar Shah, Kathleen Seidel, Huiling Tan, John-Stuart Brittain, Katrin Petermann, Lazzaro di Biase and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 161 citations in OpenAlex.

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  5. Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 4 countries.

Gerd TinkhauserMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Alek PogosyanMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Ines DeboveDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
Andreas NowackiDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Syed Ahmar ShahMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Kathleen SeidelDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Huiling TanMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
John-Stuart BrittainMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Katrin PetermannDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
Lazzaro di BiaseMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8753-757X
Markus OertelDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Claudio PolloDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Peter BrownMRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Michael SchuepbachDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
University of Bern · CHNuffield Orthopaedic Centre · GBUniversità Campus Bio-Medico · IT

Funding

Department of HealthMedical Research Council MC_UU_12024/1Medical Research Council MR/N003446/1Medical Research Council MR/P012272/1
6 · The paper itself

Abstract

backgroundAlthough recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.

objectivesHere, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.

methodsIntraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.

resultsNormalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.

conclusionLocal field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Indexed as

AgedBeta RhythmCohort StudiesDeep Brain StimulationElectrodes, ImplantedElectroencephalographyFemaleHumansMaleMiddle AgedParkinson DiseasePredictive Value of TestsSubthalamic NucleusTreatment OutcomeDBS programmingdeep brain stimulationdirectional leadslocal field potentialsParkinson's disease

Identifiers

PMID29150884
PMCPMC5768242
OpenAlexW2778986485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.