Observational studyJournal of the European Academy of Dermatology and Venereology : JEADV2018
Patient-reported health outcomes in patients with non-melanoma skin cancer and actinic keratosis: results from a large-scale observational study analysing effects of diagnoses and disease progression.
Observational study in Journal of the European Academy of Dermatology and Venereology : JEADV, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Health-related Quality of Life Measurements in Patients with Actinic Keratosis: A Systematic Review.Acta dermato-venereologica · 2026Pooled it
- Patient-reported outcomes of topical therapies in actinic keratosis: A systematic review.Dermatologic therapy · 2021Pooled it
- Health-Related Quality of Life in Patients With Different Diseases Measured With the EQ-5D-5L: A Systematic Review.Frontiers in public health · 2021Pooled it
- A WeChat-based, expert knowledge-constrained artificial intelligence health education intervention for patients undergoing gastrointestinal surgery: protocol for a randomized controlled trial.Frontiers in public health · 2026Trial
- The effectiveness of artificial intelligence health education accurately linking system on self-management in non-specific lower back pain patients.Frontiers in public health · 2025Trial
- Trial
- A Rare Case of Morpheaform Basal Cell Carcinoma With Lacrimal Sac Invasion.Case reports in surgery · 2026Article
- Effect of an artificial intelligence health education accurately linking system on self-management in young and middle-aged patients after percutaneous coronary intervention: a protocol.Frontiers in cardiovascular medicine · 2026Article
- Photoaging and Cosmetic Result with Artificial Daylight Photo-dynamic Therapy Using Methyl Aminolevulinate.Acta dermato-venereologica · 2025Article
- Epidemiology and Risk Factors of Actinic Keratosis. What is New for The Management for Sun-Damaged Skin.Dermatology practical & conceptual · 2024Review
- A European Consensus on the Consistent Use of the Term "Keratinocyte Cancer".Acta dermato-venereologica · 2024Article
- Impact of a mobile health intervention based on multi-theory model of health behavior change on self-management in patients with differentiated thyroid cancer: protocol for a randomized controlled trial.Frontiers in public health · 2024Article
- Health-related quality of life and associated factors among non-melanoma skin cancer patients: a cross-sectional study.Annals of translational medicine · 2023Article
- Positive association between actinic keratosis and internal malignancies: a nationwide population-based cohort study.Scientific reports · 2021Article
- Health utilities for non-melanoma skin cancers and pre-cancerous lesions: A systematic review.Skin health and disease · 2021Article
- A structured review of quality of life in advanced and high-risk cutaneous squamous cell carcinoma shows the need for more studies and better measures.Skin health and disease · 2021Review
- Article
- Sex Differences in Health-related Quality of Life in Patients with Keratinocyte Carcinomas.Acta dermato-venereologica · 2021Article
- [Decision criteria and patient characteristics for patient-oriented treatment of field cancerization : Standardized algorithm for personalized treatment concepts].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Article
- Quality of Life in Patients with Surgically Removed Skin Tumors.Medicina (Kaunas, Lithuania) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-melanoma skin cancer (NMSC) and actinic keratosis (AK) are very common among fair-skinned individuals. A disease continuum from AK to squamous cell carcinoma (SCC) has been frequently postulated. AK and NMSC may influence quality of life (QL) of patients, and it can be suspected that disease progression entails a QL reduction. The purpose of this study was to document QL in patients with NMSC and AK using the health-outcome questionnaire EQ-5D-5L.
methodsThe study was designed as a non-interventional, prospective, cross-sectional study. Patients with AK, SCC, basal cell carcinoma (BCC) or multiple diagnoses were enrolled in this study in 29 dermatological centres across Germany. Patients were asked to complete the EQ-5D-5L (compromising EQ Index and EQ VAS), and the dermatologists provided diagnosis, disease history and treatment data.
resultsA total of 1184 patients were enrolled and diagnosed as follows: 73% AK, 49% BCC and 17% SCC. 66% had a single diagnosis, 28% two different diagnoses and 6% three different diagnoses. QL was strongly associated with patients' diagnosis. Patients with a single AK diagnosis had significantly higher mean EQ VAS (78) than patients with BCC (74), SCC (72), and BCC plus SCC (69), P < 0.050. When the effects of disease progression were calculated, patients with AK plus SCC reported significantly less mean EQ VAS (71) than patients with a single AK diagnosis (78), P < 0.011.
conclusionsWhile rarely being imminently life-threatening, NMSC and AK have an impact on QL as quantified by the EQ-5D-5L. This impact is associated with diagnosis (AK vs. NMSC) and clinical progression (AK vs. AK plus SCC). Both lead to a clear decline in QL. This shows that disease progression is perceived and judged as detrimental by patients and that AK and NMSC should be diligently treated to preserve and restore QL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.