ArticleEuropean journal of immunology2018
IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model.
Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance.Nature communications · 2026Article
- Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance.bioRxiv : the preprint server for biology · 2024Article
- IL-22 in Atopic Dermatitis.Cells · 2024Review
- Anti-cytokine autoantibodies: mechanistic insights and disease associations.Nature reviews. Immunology · 2024Review
- Pathogenesis and virulence ofVirulence · 2022Review
- A gut-oral microbiome-driven axis controls oropharyngeal candidiasis through retinoic acid.JCI insight · 2022Article
- Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.Cell host & microbe · 2022Article
- Persistently Increased Anti-cytokine Antibodies Without Clinical Disease in a Boy with APS1 Genotype.Journal of clinical immunology · 2022Article
- Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.Cell reports · 2022Article
- The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.Frontiers in cellular and infection microbiology · 2022Article
- Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling AgainstJournal of inflammation research · 2022Article
- Infections in the monogenic autoimmune syndrome APECED.Current opinion in immunology · 2021Review
- Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis.Science immunology · 2020Article
- Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.PLoS neglected tropical diseases · 2020Article
- IL-22 Paucity in APECED Is Associated With Mucosal and Microbial Alterations in Oral Cavity.Frontiers in immunology · 2020Article
- Review
- Clinical features of Sjögren's syndrome patients with autoantibodies against interferons.Clinical and translational medicine · 2019Article
- The Interleukin-20 Cytokines in Intestinal Diseases.Frontiers in immunology · 2018Review
- Autoantibodies to Chemokines and Cytokines Participate in the Regulation of Cancer and Autoimmunity.Frontiers in immunology · 2018Review
- Chronic Mucocutaneous Candidiasis in Autoimmune Polyendocrine Syndrome Type 1.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Protection against mucocutaneous candidiasis depends on the T helper (Th)17 pathway, as gene defects affecting its integrity result in inability to clear Candida albicans infection on body surfaces. Moreover, autoantibodies neutralizing Th17 cytokines have been related to chronic candidiasis in a rare inherited disorder called autoimmune polyendocriopathy candidiasis ectodermal dystrophy (APECED) caused by mutations in autoimmune regulator (AIRE) gene. However, the direct pathogenicity of these autoantibodies has not yet been addressed. Here we show that the level of anti-IL17A autoantibodies that develop in aged Aire-deficient mice is not sufficient for conferring susceptibility to oropharyngeal candidiasis. However, patient-derived monoclonal antibodies that cross-react with murine IL-22 increase the fungal burden on C. albicans infected mucosa. Nevertheless, the lack of macroscopically evident infectious pathology on the oral mucosa of infected mice suggests that additional susceptibility factors are needed to precipitate a clinical disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.