Evidence map›Paper›PMID 29150739›Full record

ReviewTranslational stroke research2018

Cell Therapy in Stroke-Cautious Steps Towards a Clinical Treatment.

Olivier Detante, Keith Muir, Jukka Jolkkonen

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Translational stroke research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Olivier DetanteStroke Unit, Neurology Department, Grenoble Hospital, Grenoble, France.
Keith MuirInstitute of Neuroscience & Psychology, University of Glasgow, University of Glasgow, Glasgow, Scotland, UK.
Jukka JolkkonenDepartment of Neurology, University of Eastern Finland, Kuopio, Finland. jukka.jolkkonen@uef.fi.ORCID 0000-0002-9858-0204
Inserm · FRQueen Elizabeth University Hospital · GBUniversity of Eastern Finland · FI

Funding

Horizon 2020 Framework Programme 681044
6 · The paper itself

Abstract

In the future, stroke patients may receive stem cell therapy as this has the potential to restore lost functions. However, the development of clinically deliverable therapy has been slower and more challenging than expected. Despite recommendations by STAIR and STEPS consortiums, there remain flaws in experimental studies such as lack of animals with comorbidities, inconsistent approaches to experimental design, and concurrent rehabilitation that might lead to a bias towards positive results. Clinical studies have typically been small, lacking control groups as well as often without clear biological hypotheses to guide patient selection. Furthermore, they have used a wide range of cell types, doses, and delivery methods, and outcome measures. Although some ongoing and recent trial programs offer hints that these obstacles are now being tackled, the Horizon2020 funded RESSTORE trial will be given as an example of inconsistent regulatory requirements and challenges in harmonized cell production, logistic, and clinical criteria in an international multicenter study. The PISCES trials highlight the complex issues around intracerebral cell transplantation. Therefore, a better understanding of translational challenges is expected to pave the way to more successful help for stroke patients.

Indexed as

AnimalsCell- and Tissue-Based TherapyClinical Trials as TopicHumansStrokeTranslational Research, BiomedicalCell therapyCerebrovascular diseasesClinical trialsExperimental studiesTranslation

Identifiers

PMID29150739
OpenAlexW2770304367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.