ArticleClinical neuroradiology2019
Computed Tomography Perfusion is a Useful Adjunct to Computed Tomography Angiography in the Diagnosis of Brain Death.
Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 38 citations in OpenAlex.
- Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review.Tomography (Ann Arbor, Mich.) · 2024Review
- Rethinking Brain Death-Why "Dead Enough" Is Not Good Enough: The UDDA Revision Series.Neurology · 2023Article
- Cerebral blood vessels and perfusion in the pediatric brain death: five cases studied by neuroimaging.Neuroradiology · 2022Article
- Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure.Journal of clinical medicine · 2021Article
- Assessment of Cerebral Circulatory Arrest via CT Angiography and CT Perfusion in Brain Death Confirmation.Korean journal of radiology · 2021Article
- Arterial spin labeling in neonatal magnetic resonance imaging - first experience and new observations.Polish journal of radiology · 2021Article
- South African guidelines on the determination of death.The Southern African journal of critical care : the official journal of the Critical Care Society · 2021Article
- Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age.Anaesthesiology intensive therapy · 2021Article
- Neurological determination of death in isolated brainstem lesions: A case report to highlight the issues involved.Journal of the Intensive Care Society · 2020Article
- Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Utility of brain parenchyma density measurement and computed tomography perfusion imaging in predicting brain death.Polish journal of radiology · 2020Article
- Reply to Letter to the Editor "Neuroimaging of Intracranial Perfusion and the Clinical Diagnosis of Brain Death: Setting the Gold Standard in Humans".Clinical neuroradiology · 2019Article
- Neuroimaging of Intracranial Perfusion and the Clinical Diagnosis of Brain Death: Setting the Gold Standard in Humans.Clinical neuroradiology · 2019Article
- Comparison of Two Apnea Test Methods, Oxygen Insufflation and Continuous Positive Airway Pressure During Diagnosis of Brain Death: Final Report.Neurocritical care · 2019Article
- Article
- The Role of Neuroimaging in the Determination of Brain Death.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundIn the diagnosis of brain death (BD), computed tomography angiography (CTA) results in some cases show intracranial filling, leading to diagnostic confusion. Because cerebral circulatory arrest commences at the capillary level, we hypothesized that computed tomography perfusion (CTP) would be a more sensitive approach than CTA; therefore, the aim of the study was to compare the sensitivities of CTP and CTA in the diagnosis of BD. MATERIAL AND
methodsWhole brain CTP was performed in patients in the intensive care unit diagnosed with BD and CTA was derived from CTP datasets. Cerebral blood flow (CBF) and volume (CBV) were calculated in all brain regions. The CTP findings were interpreted as being consistent with a diagnosis of BD (positive) when CBF and CBV in all regions of interest (ROIs) were below 10 ml/100 g/min and 1.0 ml/100 g, respectively. The CTA findings were interpreted using a 4-point grading system.
resultsA total of 50 patients were included in the study. The CTP results revealed CBF from 0.00 to 9.98 ml/100 g/min (mean, 1.98 ± 1.68 ml/100 g/min) and CBV from 0.00 to 0.99 ml/100 g (mean, 0.14 ± 0.12 ml/100 g) and were thus interpreted as positive in all 50 patients. In contrast, the CTA results suggested 7 negative cases, providing a sensitivity of 86%. The difference between the CTP and CTA sensitivity results for the diagnosis of BD was statistically significant (p = 0.006).
conclusionWhole brain CTP may potentially be a feasible and highly sensitive test for diagnosing BD: therefore, performing CTP in combination with CTA in cases when CTA results are negative for BD could increase the sensitivity of CTA.
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