ArticleScientific reports2017
A molecular mechanism of symmetry breaking in the early chick embryo.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- A network of transient domains for breaking symmetry during anterior-posterior axis formation in the porcine embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo.Science advances · 2023Article
- 'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours.Development (Cambridge, England) · 2022Article
- Caudal duplication syndrome: a literature review and reappraisal of its pathoembryogenesis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Expression patterns of signalling molecules and transcription factors in the early rabbit embryo and their significance for modelling amniote axis formation.Development genes and evolution · 2021Article
- Cellular processes driving gastrulation in the avian embryo.Mechanisms of development · 2020Review
- From genes to environment in shaping of an embryo: understanding embryonic-extraembryonic interactions at the BSDB autumn meeting in Oxford.Development genes and evolution · 2019Article
- Embryonic Chicken (Comparative medicine · 2019Review
- Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals.Scientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The first obvious sign of bilateral symmetry in mammalian and avian embryos is the appearance of the primitive streak in the future posterior region of a radially symmetric disc. The primitive streak marks the midline of the future embryo. The mechanisms responsible for positioning the primitive streak remain largely unknown. Here we combine experimental embryology and mathematical modelling to analyse the role of the TGFβ-related molecules BMP4 and Vg1/GDF1 in positioning the primitive streak. Bmp4 and Vg1 are first expressed throughout the embryo, and then become localised to the future anterior and posterior regions of the embryo, where they will, respectively, inhibit or induce formation of the primitive streak. We propose a model based on paracrine signalling to account for the separation of the two domains starting from a homogeneous array of cells, and thus for the topological transformation of a radially symmetric disc to a bilaterally symmetric embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.