ArticleScientific reports2017
Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study.Nutrients · 2020Trial
- Production of Biodegradable Film Containing Wheat Leaf Fiber and Protein Isolate, Reinforced With Encapsulated Silver Oxide Nanocomposite, as a Color Indicator for Monitoring the Spoilage of Minced Chicken Meat.Food science & nutrition · 2026Article
- Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria.NPJ biofilms and microbiomes · 2026Article
- Type I Arabinogalactan and Methyl-Esterified Homogalacturonan Polysaccharides from Tamarillo (Pharmaceuticals (Basel, Switzerland) · 2025Article
- Structural characterization of strawberry pomace.Heliyon · 2024Article
- Polysaccharides from Passion Fruit Peels: From an Agroindustrial By-Product to a Viable Option for 5-FU-Induced Intestinal Damage.Pharmaceuticals (Basel, Switzerland) · 2023Article
- LC-ESI-MS phenolic contents assessment, antioxidant, and protective ability ofToxicology research · 2023Article
- Anti-Obesity Effects of Dietary Fibers Extracted from Flaxseed Cake in Diet-Induced Obese Mice.Nutrients · 2023Article
- Dietary fiber pectin: challenges and potential anti-inflammatory benefits for preterms and newborns.Frontiers in nutrition · 2023Review
- Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice.Oxidative medicine and cellular longevity · 2022Article
- Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis.Frontiers in physiology · 2021Review
- Mucin Thin Layers: A Model for Mucus-Covered Tissues.International journal of molecular sciences · 2019Article
- The fate of cellulose nanocrystal stabilised emulsions after simulated gastrointestinal digestion and exposure to intestinal mucosa.Nanoscale · 2019Article
- Gastrointestinal and metabolic effects of noodles-based konjac glucomannan in rats.Food & nutrition research · 2019Article
- Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate the enhancement of intestinal mucin (Muc2) binding to plant cell wall structures from fruit (parenchymal apple tissue) and grain (wheat endosperm) mediated by soluble dietary fibers embedded within cellulose networks. Mucin binding occurs through two distinct mechanisms; for pectin polysaccharides characteristic of fruits and vegetables, it is governed by molecular mucoadhesive interactions, while for neutral polysaccharides, arabinoxylan and β-glucan characteristic of cereal grains, the interaction stems from the properties of their polymer network. Based on microrheological and microscopic measurements, we show that neutral dietary fiber polysaccharides do not adhere to intestinal mucin, but are capable of disrupting the mucin network, which facilitates interpenetration of mucin molecules into the polysaccharide mesh. This effect becomes significant in the context of 'whole foods', where soluble fibers are incorporated within the gel-like matrix of cellulose-reinforced plant cell wall structures. The result of mucoadhesion assay and analysis of microscopy images points to the critical role of entanglements between mucin and polysaccharides as a lock-in mechanism preventing larger mucin from escaping out of plant cell wall structures. These results provide the first indication that non-pectin soluble dietary fiber may influence mucosal interactions, mucus barrier properties, and transmucosal transport of nutrients.
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