ArticleScientific reports2017
Semiquantative Visual Assessment of Sub-solid Pulmonary Nodules ≦3 cm in Differentiation of Lung Adenocarcinoma Spectrum.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- East-West Disparities in Lung Cancer Screening: Subsolid Nodule Prevalence, Interval Growth, and Decision-Making Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Preoperative evaluation of solitary pulmonary nodules and adenocarcinoma invasiveness using ultra-high-resolution computed tomography and multidimensional liquid biopsy: a prospective exploratory study.Frontiers in oncology · 2026Article
- An Enhanced CT-based Radiomics Model for Predicting the Anaplastic Lymphoma Kinase Mutation Status in Lung Adenocarcinoma.Current medical imaging · 2025Article
- Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography.Journal of cardiothoracic surgery · 2024Article
- Nomogram for predicting invasive lung adenocarcinoma in small solitary pulmonary nodules.Frontiers in oncology · 2024Article
- Thin-slice computed tomography enables to classify pulmonary subsolid nodules into pre-invasive lesion/minimally invasive adenocarcinoma and invasive adenocarcinoma: a retrospective study.Scientific reports · 2023Article
- Long-term follow-up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part-solid ground-glass nodules.Thoracic cancer · 2023Article
- An integrated nomogram combined semantic-radiomic features to predict invasive pulmonary adenocarcinomas in subjects with persistent subsolid nodules.Quantitative imaging in medicine and surgery · 2023Article
- Radiomics in Early Lung Cancer Diagnosis: From Diagnosis to Clinical Decision Support and Education.Diagnostics (Basel, Switzerland) · 2022Review
- Development and Validation of a Preoperative CT-Based Nomogram to Differentiate Invasive from Non-Invasive Pulmonary Adenocarcinoma in Solitary Pulmonary Nodules.Cancer management and research · 2022Article
- The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management.Frontiers in oncology · 2022Review
- Molecular typing of lung adenocarcinoma with computed tomography and CT image-based radiomics: a narrative review of research progress and prospects.Translational cancer research · 2021Review
- Predicting the histological invasiveness of pulmonary adenocarcinoma manifesting as persistent pure ground-glass nodules by ultra-high-resolution CT target scanning in the lateral or oblique body position.Quantitative imaging in medicine and surgery · 2021Article
- Discriminating invasive adenocarcinoma among lung pure ground-glass nodules: a multi-parameter prediction model.Journal of thoracic disease · 2021Article
- [Expert Consensus for Thermal Ablation of Pulmonary Subsolid Nodules (2021 Edition)].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021Article
- A comparative study to evaluate CT-based semantic and radiomic features in preoperative diagnosis of invasive pulmonary adenocarcinomas manifesting as subsolid nodules.Scientific reports · 2021Article
- Assessing invasiveness of subsolid lung adenocarcinomas with combined attenuation and geometric feature models.Scientific reports · 2020Article
- Predicting malignancy: subsolid nodules detected on LDCT in a surgical cohort of East Asian patients.Journal of thoracic disease · 2020Article
- The fate of subsolid nodule: predictable or unpredictable?Journal of thoracic disease · 2020Article
- Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts.Scientific reports · 2019Article
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Abstract
We aimed to analyze CT features of persistent subsolid nodules (SSN) ≦3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate whether parameters enable distinction between invasive pulmonary adenocarcinomas (IPAs) and pre-invasive lesions. A total of 129 patients with 141 SSNs confirmed with surgically pathologic proof were retrospectively reviewed. Of 141 SSNs, there were 57 pure ground-glass nodules (GGNs), 22 heterogeneous GGNs, and 62 part-solid nodules. SSN subclassification showed a significant linear trend with invasive degree of the adenocarcinoma spectrum (pure GGNs 7%; heterogeneous GGNs 36.4%; part-solid nodules 85.5%, P for trend <0.0001). For IPA detection in 141 SSNs, a solid part of ≧3 mm was the most specificity (sensitivity, 76.9%; specificity, 94.7%), followed by air-bronchogram sign (sensitivity, 53.8%; specificity, 89.5%), SSN subclassification (sensitivity, 81.5%; specificity, 88.2%), and a lesion size ≧12 mm (sensitivity, 84.6%; specificity, 76.3%). For IPA detection in 79 pure or heterogeneous GGNs, the heterogeneous GGN sign was the most useful finding, with most specificity (sensitivity, 66.7%; specificity, 79.1%), followed by CT attenuation (HU) of ≧-493 (sensitivity, 75%; specificity, 74.6%) and a lesion size ≧10 mm (sensitivity, 83.3%; specificity, 70.1%). In conclusion, this simple combined visual and semiquantitative analysis of CT features helps distinguish IPAs from pre-invasive lesions.
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