ArticleScientific reports2017
The role of forelimb motor cortex areas in goal directed action in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
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- Motor cortex directly excites the substantia nigra pars reticulata, the basal ganglia output nucleus.Nature communications · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Movement representations in motor, somatosensory, and posterior parietal cortex of the greater galago.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels.bioRxiv : the preprint server for biology · 2025Article
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- Diversification of pectoral control through motor pool extension.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- The mouse motor system contains multiple premotor areas and partially follows human organizational principles.Cell reports · 2024Article
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.Cell reports · 2024Article
- Exploration biases forelimb reaching strategies.Cell reports · 2024Article
- Recording Forelimb Muscle Activity in Head-Fixed Mice with Chronically Implanted EMG Electrodes.Journal of visualized experiments : JoVE · 2024Article
- FABEL: Forecasting Animal Behavioral Events with Deep Learning-Based Computer Vision.bioRxiv : the preprint server for biology · 2024Article
- Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mammalian motor cortex consists of several interconnected subregions thought to play distinct roles in voluntary movements, yet their specific role in decision making and execution is not completely elucidated. Here we used transient optogenetic inactivation of the caudal forelimb area (CFA) and rostral forelimb area (RFA) in mice as they performed a directional joystick task. Based on a vibrotactile cue applied to their forepaw, mice were trained to push or pull a joystick after a delay period. We found that choice and execution are temporally segregated processes. CFA and RFA were both essential during the stimulus delivery for correct choice and during the answer period for motor execution. Fine, distal motor deficits were restricted to CFA inactivation. Surprisingly, during the delay period neither area alone, but only combined inactivation was able to affect choice. Our findings suggest transient and partially distributed neural processing of choice and execution across different subregions of the motor cortex.
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