ArticleScientific reports2017
Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 107 citations in OpenAlex.
- Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression.Molecular psychiatry · 2025Trial
- Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression.Translational psychiatry · 2019Trial
- Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation.Translational psychiatry · 2026Article
- Sociodemographic characteristics of suicide attempters treated in the emergency department and the effect of psychological care.World journal of psychiatry · 2026Article
- Differences in white matter structural networks in family risk of major depressive disorder and suicidality: A connectome analysis.Journal of affective disorders · 2026Article
- Emerging Medications for Treatment-Resistant Depression: A Review with Perspective on Mechanisms and Challenges.Brain sciences · 2025Review
- Biomarkers of Suicidal Ideation in Depression: Insights From VMHC Analysis and Machine Learning.Neuropsychiatric disease and treatment · 2025Article
- Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis.Frontiers in psychiatry · 2025Article
- Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts.Brain imaging and behavior · 2024Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- An International Classification of Functioning, Disability and Health Model-Based Analysis of Suicidal Ideation among 9920 Community-Dwelling Korean Older Adults.Healthcare (Basel, Switzerland) · 2024Article
- Emotion-related impulsivity and suicidal ideation and behavior in schizophrenia spectrum disorder: a pilot fMRI study.Frontiers in psychiatry · 2024Article
- Classification of female MDD patients with and without suicidal ideation using resting-state functional magnetic resonance imaging and machine learning.Frontiers in human neuroscience · 2024Article
- Functional connectivity density of different suicidal behaviors in adolescents with major depressive disorders.Frontiers in psychiatry · 2024Article
- Impulsivity and Psychiatric Diagnoses as Mediators of Suicidal Ideation and Suicide Attempts Among Veterans With Traumatic Brain Injury.The Journal of neuropsychiatry and clinical neurosciences · 2024Article
- Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder.Translational psychiatry · 2023Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of transdiagnostic symptoms of anhedonia, impulsivity, and hypomania from the human functional connectome.Research square · 2023Article
- Suicidal thoughts and behaviours among military veterans: protocol for a prospective, observational, neuroimaging study.BMJ open · 2023Observational
- Depressive symptoms following traumatic brain injury are associated with resting-state functional connectivity.Psychological medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent developments in neuroimaging, alterations of brain functional connectivity in major depressive disorder (MDD) patients with suicidal ideation are poorly understood. This study investigated specific changes of suicidal ideation in functional connectivity of MDD patients. Whole brain functional connectivity in 46 patients with MDD (23 with suicidal ideation and 23 without) and 36 age- and gender- matched healthy controls were compared using resting-state functional Magnetic Resonance Imaging (fMRI) analyzed with network-based statistics (NBS) and graph-theoretical methods. Decreased functional connectivity in a characterized sub-network was observed in patients with MDD and suicidal ideation (FDR-adjusted p < 0.05). The sub-network included the regions of the fronto-thalamic circuits in the left hemisphere. The network measures of the left superior frontal gyrus, pars orbitalis (r = -0.40, p = 0.009), left thalamus (r = -0.41, p = 0.009), and right thalamus (r = -0.51, p = -0.002) were shown, through graph theoretical analysis, to be significantly negatively correlated with severity of suicidal ideation. The reduced functional connectivity in left orbitofrontal-both thalamic regions with suicidal ideation in MDD were inversely proportional to the severity of suicidality independent from depression severity. These findings suggest problems with decision-making and information integration in MDD patients with suicidal ideation.
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