Observational studyScientific reports2017
Health impact of E-cigarettes: a prospective 3.5-year study of regular daily users who have never smoked.
Observational study in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- A systematic review of the effects of e-cigarette use on lung function.NPJ primary care respiratory medicine · 2022Pooled it
- Chronic health effects associated with electronic cigarette use: A systematic review.Frontiers in public health · 2022Pooled it
- Cardiovascular autonomic effects of electronic cigarette use: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Pooled it
- Electronic Cigarette Use and Blood Pressure Endpoints: a Systematic Review.Current hypertension reports · 2020Pooled it
- Trial
- Trial
- Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026Review
- The effect of long-term e-cigarette use on the inflammation marker fractional exhaled nitric oxide (FeNO): A systematic review and meta-analysis.Tobacco induced diseases · 2026Review
- Caution required in interpreting inflammatory effects of e-cigarette use: correcting methodological and conceptual weaknesses.Respiratory research · 2025Article
- Association between electronic cigarette use and respiratory outcomes among people with no established smoking history: a comprehensive review and critical appraisal.Internal and emergency medicine · 2025Review
- Association between e-cigarette exposure and ventilation homogeneity in young adults: a cross-sectional study.The European respiratory journal · 2025Article
- International Expert Consensus on Relevant Health and Functioning Concepts to Assess in Users of Tobacco and Nicotine Products: Delphi Study.JMIR formative research · 2025Article
- Patterns of Use of e-Cigarettes and Their Respiratory Effects: A Critical Umbrella Review.Tobacco use insights · 2025Review
- Examining Vaping Policies in Substance Use Disorder Treatment Facilities.Tobacco use insights · 2025Article
- Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia.Tobacco induced diseases · 2025Article
- Association between type of smoking and smoking cessation plans in Korean adults: A nationwide cross-sectional study.Tobacco induced diseases · 2025Article
- Comparative effects of cigarette smoking, e-cigarette use, and dual use on pulmonary function, exercise capacity, and quality of life in young adults: a cross-sectional study.Frontiers in public health · 2025Article
- Impact of electronic cigarette vaping on the cardiovascular function in young and old rats.Scientific reports · 2024Article
- Respiratory symptoms among e-cigarette users without an established smoking history in the VERITAS cohort.Scientific reports · 2024Article
- The association between smoking/vaping habits and self-reported respiratory symptoms.Multidisciplinary respiratory medicine · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although electronic cigarettes (ECs) are a much less harmful alternative to tobacco cigarettes, there is concern as to whether long-term ECs use may cause risks to human health. We report health outcomes (blood pressure, heart rate, body weight, lung function, respiratory symptoms, exhaled breath nitric oxide [eNO], exhaled carbon monoxide [eCO], and high-resolution computed tomography [HRCT] of the lungs) from a prospective 3.5-year observational study of a cohort of nine daily EC users (mean age 29.7 (±6.1) years) who have never smoked and a reference group of twelve never smokers. No significant changes could be detected over the observation period from baseline in the EC users or between EC users and control subjects in any of the health outcomes investigated. Moreover, no pathological findings could be identified on HRCT of the lungs and no respiratory symptoms were consistently reported in the EC user group. Although it cannot be excluded that some harm may occur at later stages, this study did not demonstrate any health concerns associated with long-term use of EC in relatively young users who did not also smoke tobacco.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.