ArticleJournal of immunology (Baltimore, Md. : 1950)2018
The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy.MedComm · 2026Review
- Targeting MHC-E as a new strategy for vaccines and immunotherapeutics.Nature reviews. Immunology · 2026Review
- Shared HLA-E and Mamu-E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF- and Fluorescence Polarisation-Based Methods.European journal of immunology · 2026Article
- Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge.Nature communications · 2024Article
- CD8Science advances · 2024Article
- The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research.Microorganisms · 2024Review
- The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E.Frontiers in immunology · 2024Article
- Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis.Science immunology · 2023Article
- CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.PLoS pathogens · 2023Article
- Intracellular trafficking of HLA-E and its regulation.The Journal of experimental medicine · 2023Article
- Programming cytomegalovirus as an HIV vaccine.Trends in immunology · 2023Review
- CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques.bioRxiv : the preprint server for biology · 2023Article
- Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines.Communications biology · 2022Article
- A guide to antigen processing and presentation.Nature reviews. Immunology · 2022Review
- Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species.Cell host & microbe · 2022Article
- Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes.Cellular and molecular life sciences : CMLS · 2022Review
- Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.Cell reports · 2022Article
- Myd88 knockdown with RNA interference induces in vitro immune hyporesponsiveness in dendritic cells from rhesus monkeys.Immunogenetics · 2022Article
- Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance.Frontiers in immunology · 2022Article
- Discovery of HLA-E-Presented Epitopes: MHC-E/Peptide Binding and T-Cell Recognition.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 2 countries.
Helen L WuVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Roger W WisemanDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706.
Colette M HughesVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Gabriela M WebbVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-6084-4166
Shaheed A AbdulhaqqVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Benjamin N BimberOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Katherine B HammondVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-5384-1642
Jason S ReedVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Lina GaoOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Benjamin J BurwitzVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-7767-022X
Justin M GreeneVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Fidel FerrerVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Alfred W LegasseOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Michael K AxthelmOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-1984-5906
Byung S ParkOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0003-3516-7516
Simon BrackenridgeNuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 2JD, United Kingdom.ORCID 0000-0002-0587-7560
Nicholas J ManessDivision of Microbiology, Tulane National Primate Research Center, Covington, LA 70433.
Andrew J McMichaelNuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 2JD, United Kingdom.ORCID 0000-0002-9101-7478
Louis J PickerVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706.
Scott G HansenVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006.
Jonah B SachaVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006; sacha@ohsu.edu.ORCID 0000-0002-7633-3122
Oregon Health & Science University · USOregon National Primate Research Center · USNuffield Orthopaedic Centre · GBUniversity of Wisconsin–Madison · USTulane University · US
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI HARRISON, STEPHEN COPLAN · 2012 to 2018
$204.7MUpgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MWNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MVirology and Immunology MonitoringP01AI094417 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI PICKER, LOUIS J. · 2011 to 2016
$20.5MA nonhuman primate model of stem cell transplantation to understand determinants of post-transplant SIV clearanceR01AI129703 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SACHA, JONAH B. · 2017 to 2025
$7.8MIdentifying Common T Cell Responses to Major Pathogens in Rhesus MacaquesR24OD017850 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2014 to 2022
$5.8MA universal MHC-E-restricted T cell vaccine for HIVR01AI117802 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SACHA, JONAH B. · 2015 to 2018
$3.5MGENE THERAPY FOR IMMUNE DEFICIENCIESZ01AI000645 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI DE RAVIN, SUK · 1992 to 2008
$873kEstablishing a non-human primate model of HLA-E-restricted CD8+ T cellsF31AI122471 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HELEN L · 2016 to 2016
$38kIntramural NIH HHS Z01 AI000645Medical Research Council K012037/1Medical Research Council MR/K012037/1NIAID NIH HHS F31 AI122471NIAID NIH HHS P01 AI094417NIAID NIH HHS R01 AI117802NIAID NIH HHS R01 AI129703NIAID NIH HHS UM1 AI100645NIH HHS P51 OD011092NIH HHS P51 OD011104NIH HHS P51 OD011106NIH HHS R24 OD017850
Abstract
MHC-E is a highly conserved nonclassical MHC class Ib molecule that predominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation. However, MHC-E also binds pathogen-derived peptide Ags for presentation to CD8
Indexed as
AnimalsAntigen PresentationAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedConserved SequenceHistocompatibility AntigensHistocompatibility Antigens Class IHLA-E AntigensHumansKiller Cells, NaturalMacaca fascicularisMacaca mulattaModels, AnimalPeptidesAntigens, ViralHistocompatibility AntigensHistocompatibility Antigens Class IHLA-E AntigensPeptides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.