Evidence map›Paper›PMID 29150461›Full record

ArticleMolecular pharmacology2018

GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC

Gustav Akk, Daniel J Shin, Allison L Germann, Joe Henry Steinbach

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Activation of the human β3 GABABiochemical pharmacology · 2026
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  3. GABAMolecular cell · 2025
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  5. UNC-49 is a redox-sensitive GABAScience advances · 2023
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  6. Article
  7. Modulation of the mammalian GABABritish journal of pharmacology · 2022
    Article
  8. Article
  9. Article
  10. (+)-Catharanthine potentiates the GABABiochemical pharmacology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Electrophysiology of ionotropic GABA receptors.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Article
  17. Reduced Activation of the Synaptic-Type GABAMolecular pharmacology · 2020
    Article
  18. Analysis of Modulation of theMolecular pharmacology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution.

Gustav AkkDepartment of Anesthesiology (G.A., D.J.S., A.L.G., J.H.S.) and Taylor Family Institute for Innovative Psychiatric Research (G.A., J.H.S.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Daniel J ShinDepartment of Anesthesiology (G.A., D.J.S., A.L.G., J.H.S.) and Taylor Family Institute for Innovative Psychiatric Research (G.A., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Allison L GermannDepartment of Anesthesiology (G.A., D.J.S., A.L.G., J.H.S.) and Taylor Family Institute for Innovative Psychiatric Research (G.A., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Joe Henry SteinbachDepartment of Anesthesiology (G.A., D.J.S., A.L.G., J.H.S.) and Taylor Family Institute for Innovative Psychiatric Research (G.A., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Taylor Family Institute for Innovative Psychiatric Research

Funding

SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580
6 · The paper itself

Abstract

The concerted transition model for multimeric proteins is a simple formulation for analyzing the behavior of transmitter-gated ion channels. We used the model to examine the relationship between the EC

Indexed as

Models, TheoreticalAllosteric RegulationAnestheticsAnimalsBinding SitesDose-Response Relationship, DrugDrug InteractionsGABA Agonistsgamma-Aminobutyric AcidModels, BiologicalMutationOocytesPatch-Clamp TechniquesPentobarbitalPregnanedionesPropofolalphaxaloneAnestheticsGABA Agonistsgamma-Aminobutyric AcidPentobarbitalPregnanedionesPropofolReceptors, GABA-A

Identifiers

PMID29150461
PMCPMC5749490
OpenAlexW2770961089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.