Evidence map›Paper›PMID 29150447›Full record

ArticleThe Journal of biological chemistry2018

The prototypical proton-coupled oligopeptide transporter YdgR from

Bala K Prabhala, Nanda G Aduri, Neha Sharma, Aqsa Shaheen, Arpan Sharma, Mazhar Iqbal, Paul R Hansen, Christoffer Brasen, Michael Gajhede, Moazur Rahman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Analysis of a Library ofAntibiotics (Basel, Switzerland) · 2022
    Article
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  7. Article
  8. Review
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  11. Article
  12. Article
  13. Article
  14. Sulpiride Serves, a Substrate for the Gut Microbiome.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Bala K PrabhalaFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Nanda G AduriFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Neha SharmaFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Aqsa Shaheenthe Health Biotechnology Divisions, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Arpan SharmaFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Mazhar Iqbalthe Health Biotechnology Divisions, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Paul R HansenFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Christoffer BrasenFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Michael GajhedeFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and.
Moazur Rahmanthe Health Biotechnology Divisions, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Osman MirzaFrom the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark and om@sund.ku.dk.
University of Copenhagen · DKNational Institute for Biotechnology and Genetic Engineering · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chloramphenicol (Cam) is a broad-spectrum antibiotic used to combat bacterial infections in humans and animals. Cam export from bacterial cells is one of the mechanisms by which pathogens resist Cam's antibacterial effects, and several different proteins are known to facilitate this process. However, to date no report exists on any specific transport protein that facilitates Cam uptake. The proton-coupled oligopeptide transporter (POT) YdgR from

Indexed as

Biological TransportChloramphenicolEscherichia coliEscherichia coli ProteinsMembrane Transport ProteinsMutagenesis, Site-DirectedChloramphenicoldtpA protein, E coliEscherichia coli ProteinsMdfa protein, E coliMembrane Transport Proteinsantibioticsmembrane transportmolecular dockingsite-directed mutagenesistransporter

Identifiers

PMID29150447
PMCPMC5777243
OpenAlexW2770027949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.