Evidence map›Paper›PMID 29150444›Full record

ArticleThe Journal of biological chemistry2018

Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca

Jie Yang, Rui Zhang, Xin Jiang, Jingzhang Lv, Ying Li, Hongyu Ye, Wenjuan Liu, Gang Wang, Cuicui Zhang, Na Zheng and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  7. Sex-Specific Differences in LPS-Induced Rapid Myocardial Dysfunction.International journal of molecular sciences · 2025
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  13. Review
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  16. Review
  17. Article
  18. Article
  19. Article
  20. Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.European review for medical and pharmacological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Jie YangFrom the Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China.
Rui ZhangFrom the Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China.
Xin Jiangthe Department of Cardiology, Second Affiliated Hospital of Jinan University (Shenzhen People's Hospital), Shenzhen 518000, China.
Jingzhang Lvthe Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, China, and.
Ying Lithe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Hongyu Yethe Department of Cardiothoracic Surgery, Zhongshan People's Hospital, Zhongshan 528415, China.
Wenjuan Liuthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Gang Wangthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Cuicui Zhangthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Na Zhengthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Ming Dongthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Yan Wangthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Peiya Chenthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Kumar Santoshthe Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Yong JiangFrom the Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, jiang48231@163.com.
Jie LiuFrom the Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China, liuj@szu.edu.cn.
Shenzhen University · CNSouthern Medical University · CNShenzhen Entry-Exit Inspection and Quarantine Bureau · CNShenzhen Second People's Hospital · CNZhongshan People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies suggest the potential role of a sarcoplasmic reticulum (SR) Ca

Indexed as

AnimalsCalciumCells, CulturedEchocardiographyFemaleMaleMiceMice, Inbred C57BLMitochondriaMyocytes, CardiacRats, Sprague-DawleyReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSepsisSulfonamidesCalciumethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelSulfonamidestacrolimus binding protein 1BTacrolimus Binding ProteinsTetracaineToll-Like Receptor 4animal modelcalciumcardiomyocytegene knockoutmousesarcoplasmic reticulum (SR)Toll-like receptor 4 (TLR4)

Identifiers

PMID29150444
PMCPMC5777254
OpenAlexW2768679962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.