ReviewPhysics of life reviews2018
Network science of biological systems at different scales: A review.
Review in Physics of life reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
104 citing papers in PubMed.
- Statistical learning of stochastic complex systems via the Yau-Yau nonlinear filter.Innovation (Cambridge (Mass.)) · 2026Article
- ER calcium stores contribute to glucose-induced CaCell calcium · 2026Article
- Multiscale networks in Alzheimer's disease identify brain hypometabolism as central across biological scales.PLoS computational biology · 2025Article
- Creating an Interactive Web Interface for Networks Stored in Knowledge Graph Databases.Current protocols · 2025Article
- Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.Communications biology · 2025Article
- Strong and weak environmental perturbations cause contrasting restructure of ant transportation networks.Proceedings. Biological sciences · 2025Article
- Opportunity makes a hub or a leader.eLife · 2025Article
- Article
- A Deep Dynamic Causal Learning Model to Study Changes in Dynamic Effective Connectivity During Brain Development.IEEE transactions on bio-medical engineering · 2024Article
- Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical Applications.International journal of molecular sciences · 2024Review
- A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Exploring pancreatic beta-cell subgroups and their connectivity.Nature metabolism · 2024Review
- Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior.Communications biology · 2024Article
- A python library for the fast and scalable computation of biologically meaningful individual specific networks.Scientific reports · 2024Article
- Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis.PLoS computational biology · 2024Article
- Plant microphenotype: from innovative imaging to computational analysis.Plant biotechnology journal · 2024Review
- Rare disease research workflow using multilayer networks elucidates the molecular determinants of severity in Congenital Myasthenic Syndromes.Nature communications · 2024Article
- Multiscale networks in multiple sclerosis.PLoS computational biology · 2024Article
- Mechanistic description of spontaneous loss of memory persistent activity based on neuronal synaptic strength.Heliyon · 2024Article
- Assessing electrogenetic activation via a network model of biological signal propagation.Frontiers in systems biology · 2024Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Network science is today established as a backbone for description of structure and function of various physical, chemical, biological, technological, and social systems. Here we review recent advances in the study of complex biological systems that were inspired and enabled by methods of network science. First, we present research highlights ranging from determination of the molecular interaction network within a cell to studies of architectural and functional properties of brain networks and biological transportation networks. Second, we focus on synergies between network science and data analysis, which enable us to determine functional connectivity patterns in multicellular systems. Until now, this intermediate scale of biological organization received the least attention from the network perspective. As an example, we review the methodology for the extraction of functional beta cell networks in pancreatic islets of Langerhans by means of advanced imaging techniques. Third, we concentrate on the emerging field of multilayer networks and review the first endeavors and novel perspectives offered by this framework in exploring biological complexity. We conclude by outlining challenges and directions for future research that encompass utilization of the multilayer network formalism in exploring intercellular communication patterns in tissues, and we advocate for network science being one of the key pillars for assessing physiological function of complex biological systems-from organelles to organs-in health and disease.
Indexed as
Identifiers
29150402What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.