Evidence map›Paper›PMID 29150290›Full record

ArticleMedical hypotheses2017

Premature atherosclerosis in premenopausal women: Does cytokine balance play a role?

Jo-Ann Eastwood, Doris A Taylor, B Delia Johnson, Micheline Resende, Barry L Sharaf, Bina Ahmed, Margo Minissian, Chrisandra Shufelt, Noel Bairey Merz

Open access · greenAbstract read
In one paragraph

Article in Medical hypotheses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jo-Ann EastwoodUniversity of California Los Angeles, United States. Electronic address: jeastwood@sonnet.ucla.edu.
Doris A TaylorTexas Heart Institute, Houston, United States.
B Delia JohnsonUniversity of Pittsburgh, United States.
Micheline ResendeTexas Heart Institute, United States.
Barry L SharafRhode Island Hospital, United States.
Bina AhmedDartmouth-Hitchcock Medical Center, United States.
Margo MinissianBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, United States.
Chrisandra ShufeltBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, United States.
Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, United States.
Cedars-Sinai Smidt Heart Institute · USDartmouth–Hitchcock Medical Center · USRhode Island Hospital · USUniversity of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Women's Ischemia Syndrome EvaluationU01HL064829 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F. · 2001 to 2005
$3.9M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Renin Angiotensin for Coronary Microvascular DysfunctionU01HL064924 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2001 to 2005
$2.0M
Behavioral Medicine and Cardiovascular Research TrainingT32HL069751 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI KRANTZ, DAVID S. · 2003 to 2007
$1.2M
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young WomenK23HL127262 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHUFELT, CHRISANDRA LEE · 2016 to 2020
$988k
Functional MRI of the pharyngeal airwayR01HL068162 · NHLBI · UNIVERSITY OF ARIZONA · PI FREGOSI, RALPH FRANK · 2003 to 2005
$899k
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTERN01HV068161 · HV · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, WILLIAM J · 1996 to 2000
$245k
Cardiovascular Events in Women's Ischemia Syndrome EvaluationR03AG032631 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F · 2008 to 2009
$137k
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTRN01HV068164 · HV · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI REICHEK, NATHANIEL · 1996 to 2001
–
NCATS NIH HHS UL1 TR000124NCRR NIH HHS M01 RR000425NHLBI NIH HHS K23 HL127262NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL090957NHLBI NIH HHS T32 HL069751NHLBI NIH HHS U01 HL064829NHLBI NIH HHS U01 HL064924NIA NIH HHS R03 AG032631
6 · The paper itself

Abstract

Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the profile of circulating cytokines reflects both endothelial integrity and the presence of immune and progenitor cells. Significant differences in pro- and anti-inflammatory cytokine concentrations between patients with and without CAD exist. Young women with obstructive CAD may experience differences in pro-inflammatory cytokines and the recruitment of reparative cells that secrete T-Helper (Th2 cytokines compared to women without CAD. Thus, cytokine balance may play a role in obstructive CAD in young women. In this pilot study we set out to identify an array of circulating inflammatory marker profiles which could be useful for the development of risk assessment and preventive strategies. We tested the hypothesis that an increase in serologic Th1 cytokines relative to Th2)/hematopoietic regulatory (HR) cytokines is related to premature coronary atherosclerosis in premenopausal women.

Indexed as

PremenopauseAdultAtherosclerosisBiomarkersCoronary AngiographyCytokinesEndothelial CellsFemaleHumansImmune SystemInflammationMiddle AgedModels, BiologicalPilot ProjectsRisk AssessmentRisk FactorsBiomarkersCytokines

Identifiers

PMID29150290
PMCPMC5728183
OpenAlexW2760794214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.