ArticleImmunity2017
A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.
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Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Protective coinfection: influenza reprograms myeloid cells to limit CD8 T cell-mediated malaria pathology.Research square · 2026Article
- Delineating the short- and long-term impact of ionizing radiation on antigen-inexperienced CD8+ T cell subsets.JCI insight · 2025Article
- Highly cross-reactive and competent effectors dominate the CD8+ T cell response in Trypanosoma cruzi infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- A frameshift-generated cancer neoepitope that controls tumor burden in prophylaxis as well as therapy.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.PLoS pathogens · 2025Article
- Integrated Methodology from Synthesis toNano letters · 2025Article
- Structural and Dynamic-Based Characterization of the Recognition Patterns of E7 and TRP-2 Epitopes by MHC Class I Receptors through Computational Approaches.International journal of molecular sciences · 2024Article
- Pathogenetic mechanisms and treatment targets in cerebral malaria.Nature reviews. Neurology · 2023Review
- Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study.Frontiers in immunology · 2022Article
- TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers.International journal of molecular sciences · 2020Review
- Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope.The Journal of biological chemistry · 2020Article
- The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease.Viral immunology · 2020Review
- Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research.Experimental animals · 2019Review
- T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019Review
- Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells.The Journal of clinical investigation · 2019Article
- Generation of T Cell Receptor Retrogenic Mice.Current protocols in immunology · 2019Article
- Monocyte-Derived CD11cCell host & microbe · 2019Article
- Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.Scientific reports · 2018Article
- T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.Nature chemical biology · 2018Article
- Understanding the drivers of MHC restriction of T cell receptors.Nature reviews. Immunology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Natalija Van Braeckel-BudimirDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Stephanie GrasAustralian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Tracy M JosephsAustralian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Lecia PeweDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Stina L UrbanDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Kelly L MinersDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Carine FarencInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK; Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address: priced6@cardiff.ac.uk.
Jamie RossjohnAustralian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. Electronic address: jamie.rossjohn@monash.edu.
John T HartyDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-harty@uiowa.edu.
University of Iowa · USCardiff University · GBMonash University · AUAustralian Regenerative Medicine Institute · AUAustralian Research Council · AUNational Institute of Allergy and Infectious Diseases · US
Funding
TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7MRESEARCH TRAINING IN INFECTIOUS DISEASEST32AI007343 · NIAID · UNIVERSITY OF IOWA · PI STAPLETON, JACK T. · 1988 to 2024
$5.0MRegulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7MT resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4MMemory CD8 T cell immunity to Plasmodium liver stage infecR01AI085515 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2010 to 2020
$4.1MUnderstanding immune regulation in blood-stage malariaR01AI100527 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2021
$3.6MT cell immunity to Plasmodium sporozoite immunizationR01AI095178 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2016
$2.6MCD8+ T Cell effector mechanisms against L. monocytogenesR21AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T. · 2002 to 2002
$331kNIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI085515NIAID NIH HHS R01 AI095178NIAID NIH HHS R01 AI100527NIAID NIH HHS R21 AI042767NIAID NIH HHS R37 AI042767NIAID NIH HHS T32 AI007260NIAID NIH HHS T32 AI007343NIAID NIH HHS T32 AI007511Wellcome TrustWellcome Trust 100326/Z/12/Z
Abstract
Immune response (Ir) genes, originally proposed by Baruj Benacerraf to explain differential antigen-specific responses in animal models, have become synonymous with the major histocompatibility complex (MHC). We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was required for CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesComplementarity Determining RegionsEpitopesGenes, T-Cell Receptor betaHistocompatibility Antigen H-2DMiceMice, Inbred BALB CMice, Inbred C57BLPeptide FragmentsPlasmodium bergheiProtozoan ProteinsReceptors, Antigen, T-CellComplementarity Determining RegionsEpitopesHistocompatibility Antigen H-2DPeptide FragmentsProtozoan ProteinsReceptors, Antigen, T-Cellexperimental cerebral malariaimmune response genesmalarianaive CD8(+) T cellsTCR bias
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.