Evidence map›Paper›PMID 29149933›Full record

ReviewCritical care clinics2018

Nutrition Therapy in Sepsis.

Paul E Wischmeyer

Registry-linked trialAbstract readReview
In one paragraph

Review in Critical care clinics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07329595 (Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07329595 recruitingnot on this mapstarted 2023, after this paper: background citation

Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury

TypeobservationalSponsorTamas Vegh, MDRan2023 to 2026Enrolled30ConditionsSeverely Burned Patients, Gut Microbiota Diversity and Composition, Inflammatory Responses
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Observational
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Paul E WischmeyerDepartment of Anesthesiology, Duke University School of Medicine, 2400 Pratt Street, Office: NP 7060, Durham, NC 27705, USA. Electronic address: Paul.Wischmeyer@Duke.edu.
Duke University · US

Funding

Supplemental Parenteral Nutrition to Reduce Death in Malnourished ICU PatientsR34HL109369 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HEYLAND, DAREN KEITH, WISCHMEYER, PAUL E · 2012 to 2014
$568k
NHLBI NIH HHS R34 HL109369
6 · The paper itself

Abstract

Sepsis is characterized by early massive catabolism, lean body mass (LBM) loss, and escalating hypermetabolism persisting for months to years. Early enteral nutrition should attempt to correct micronutrient/vitamin deficiencies, deliver adequate protein and moderated nonprotein calories, as well-nourished patients can generate reasonable endogenous energy. After resuscitation, increasing protein/calories are needed to attenuate LBM loss and promote recovery. Malnutrition screening is essential, and parenteral nutrition can be safely added when enteral nutrition is failing based on preillness malnutrition. Following discharge from intensive care unit, significantly increased protein/calorie delivery is required for months to years to facilitate functional and LBM recovery.

Indexed as

Practice Guidelines as TopicCritical CareCritical IllnessEnteral NutritionHumansNutritional SupportParenteral NutritionSepsisCaloriesEnteral nutritionLean body massLipidsParenteral nutritionProtein

Identifiers

PMID29149933
PMCPMC6447319
OpenAlexW2762917476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.