ArticleBMC neurology2017
Predictors of early-onset post-ischemic stroke depression: a cross-sectional study.
Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association Between Peripheral IL-6 Levels in the Acute Stage of Stroke and Poststroke Depression: A Systematic Review and Meta-Analysis.Brain and behavior · 2026Pooled it
- Repetitive transcranial magnetic stimulation for treating post-stroke depression: a systematic review and network meta-analysis.BMC psychiatry · 2025Pooled it
- State of the science in inflammation and stroke recovery: A systematic review.Annals of physical and rehabilitation medicine · 2022Pooled it
- Neurotrophins Plasma Levels Kinetics in Ischemic Stroke Patients-Potential Relation to Outcomes.Neurology international · 2026Article
- Influencing factors and predictive models of early post-stroke depression in patients with acute ischemic stroke.BMC neurology · 2025Article
- Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression.Molecular neurobiology · 2024Review
- Intravenous thrombolysis and risk of early-onset post-stroke depression: a propensity score matched cohort study.Frontiers in neurology · 2024Article
- From stroke to depression: The need for systematic screening for post-stroke depression.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects.Stroke and vascular neurology · 2023Article
- The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients.Journal of clinical laboratory analysis · 2022Article
- Blood biomarkers of post-stroke depression after minor stroke at three months in males and females.BMC psychiatry · 2022Article
- Initiation of antidepressants in young adults after ischemic stroke: a registry-based follow-up study.Journal of neurology · 2022Article
- Prevalence and risk factors of stroke-related sarcopenia at the subacute stage: A case control study.Frontiers in neurology · 2022Article
- The etiologies of post-stroke depression: Different between lacunar stroke and non-lacunar stroke.Clinics (Sao Paulo, Brazil) · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- A sudden and severe depressive episode after a left cingulate gyrus stroke: a case report of post-stroke depression and review of literature.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression.Journal of clinical medicine · 2021Review
- Reduced Plasma Dopamine-β-Hydroxylase Activity Is Associated With the Severity of Bipolar Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up.International journal of environmental research and public health · 2020Observational
- PREDICTORS OF EARLY-ONSET DEPRESSION AFTER FIRST-EVER STROKE.Acta clinica Croatica · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPost-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD.
methodsPatients with an acute ischemic stroke, who met the inclusion criteria at Shanghai Tenth People's Hospital from April 2016 to September 2016, were recruited for this study. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and the mental state was assessed using Mini-Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) at 1 week of admission. The patients were divided into PSD and non-PSD groups. The demographic and clinical characteristics, as well as the biochemical factors, were compared between the two groups. A logistic regression analysis was performed to identify the risk factors for depression following stroke.
resultsA total of 83 patients with acute ischemic stroke were recruited. Of these, 36 (43.4%) developed depression. The multivariate logistic regression analysis indicated that high NIHSS [odds ratio (OR): 1.84, 95% confidence interval (CI): 1.09-3.12, P = 0.023] and high HAMD scores (OR: 2.38, 95% CI: 1.61-3.50, P < 0.001) were independent risk predictors for PSD and so were lower dopamine level (OR: 0.64, 95% CI: 0.45-0.91, P = 0.014), lower 5-hydroxytryptamine level (OR: 0.99, 95% CI: 0.98-1.00, P = 0.046), higher tumor necrosis factor-α level (OR: 1.05, 95% CI: 1.00-1.09, P = 0.044), and lower nerve growth factor level (OR: 0.06, 95% CI: 0.01-0.67, P = 0.022).
conclusionsThe identification of higher NIHSS scores, higher HAMD scores, lower dopamine level, lower 5-hydroxytryptamine level, higher tumor necrosis factor-α level, and lower nerve growth factor level might be useful for clinicians in recognizing and treating depression in patients after a stroke.
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