Evidence map›Paper›PMID 29149876›Full record

ArticleBMC ophthalmology2017

Impact of donor graft quality on deep anterior lamellar Keratoplasty (DALK).

Friederike Schaub, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl

Open access · goldAbstract read
In one paragraph

Article in BMC ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Cornea Procurement and Processing up to 72 Hours: No Risk for Cornea Transplant Quality.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021
    Article
  8. Article
  9. Deep anterior lamellar keratoplasty: A surgeon's guide.Journal of current ophthalmology · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Friederike SchaubDepartment of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. friederike.schaub@uk-koeln.de.
Philip EndersDepartment of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Werner AdlerDepartment of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander University Erlangen-Nürnberg, Waldstr. 6, 91054, Erlangen, Germany.
Björn O BachmannDepartment of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Claus CursiefenDepartment of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Ludwig M HeindlDepartment of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
University of Cologne · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

Deutsche Forschungsgemeinschaft FOR2240European Cooperation in Science and Technology BM1302
6 · The paper itself

Abstract

backgroundTo evaluate main features of donor tissue that may influence clinical outcome or complication rate after deep anterior lamellar keratoplasty (DALK).

methodsDonor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between June 2011 and December 2014 in 84 eyes of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of recipient eyes 12 months after surgery and 3 months after total suture removal. Main donor tissue parameters included age), post-mortem time, overall preservation time, preservation time after split and prior to transplantation, and preservation technique. Clinical outcome parameters included best spectacle corrected visual acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD) and complication rates. Pearson's correlation, linear regression analysis for clinical outcome parameter and logistic regression analysis for postsurgical complication rates were applied.

resultsCorneal donors were mean aged 67.4 ± 12.5 years with a post-mortem time of 20.7 ± 14.7 h and ECD of 2641.0 ± 362.8 cells/mm

conclusionsDonor corneas, independent of excision techniques or preservation method, with donor age ≤ 88 years, post-mortem time ≤ 63 h, overall preservation time ≤ 14 days for cold storaged donor tissue and ≤35 days for organ culture, and preservation time after split prior to grafting ≤96 h, seem to be applicable as safe donor tissue for DALK surgery.

Indexed as

Tissue DonorsAdultAgedAge FactorsCorneal DiseasesFemaleHumansKeratoplasty, PenetratingMaleMiddle AgedRetrospective StudiesTime-to-TreatmentTissue PreservationVisual AcuityDALKDonor tissueEye bankKeratoconusSplit cornea transplantation

Identifiers

PMID29149876
PMCPMC5693523
OpenAlexW2769983284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.