ArticleHippocampus2018
Hippocampal CA1 activity correlated with the distance to the goal and navigation performance.
Article in Hippocampus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Forming cognitive maps for abstract spaces: the roles of the human hippocampus and orbitofrontal cortex.Communications biology · 2024Article
- Conjunctive encoding of exploratory intentions and spatial information in the hippocampus.Nature communications · 2024Article
- A comparison of behavioral paradigms assessing spatial memory in tree shrews.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Differential involvement of the anterior and posterior hippocampus, parahippocampus, and retrosplenial cortex in making precise judgments of spatial distance and object size for remotely acquired memories of environments and objects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Uncovering the Hippocampal Mechanisms Underpinning Spatial Learning and Flexible Navigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Goal discrimination in hippocampal nonplace cells when place information is ambiguous.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Do hippocampal pyramidal cells respond to nonspatial stimuli?Physiological reviews · 2021Review
- The stimulus control of local enclosures and barriers over head direction and place cell spatial firing.Brain and behavior · 2021Article
- Age-related differences in brain activations during spatial memory formation in a well-learned virtual Morris water maze (vMWM) task.NeuroImage · 2019Article
- Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum.Nature communications · 2019Article
- Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Insensitivity of Place Cells to the Value of Spatial Goals in a Two-Choice Flexible Navigation Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Path integration maintains spatial periodicity of grid cell firing in a 1D circular track.Nature communications · 2019Article
- NeuroChaT: A toolbox to analyse the dynamics of neuronal encoding in freely-behaving rodentsWellcome open research · 2019Article
- Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer.Molecular neurobiology · 2018Article
- Hippocampal CA1 activity correlated with the distance to the goal and navigation performance.Hippocampus · 2018Article
- Learned Spatial Schemas and Prospective Hippocampal Activity Support Navigation After One-Shot Learning.Frontiers in human neuroscience · 2018Article
- The Complex Nature of Hippocampal-Striatal Interactions in Spatial Navigation.Frontiers in human neuroscience · 2018Article
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3 authors.
Funding
Abstract
Coding the distance to a future goal is an important function of a neural system supporting navigation. While some evidence indicates the hippocampus increases activity with proximity to the goal, others have found activity to decrease with proximity. To explore goal distance coding in the hippocampus we recorded from CA1 hippocampal place cells in rats as they navigated to learned goals in an event arena with a win-stay lose-shift rule. CA1 activity was positively correlated with the distance - decreasing with proximity to the goal. The stronger the correlation between distance to the goal and CA1 activity, the more successful navigation was in a given task session. Acceleration, but not speed, was also correlated with the distance to the goal. However, the relationship between CA1 activity and navigation performance was independent of variation in acceleration and variation in speed. These results help clarify the situations in which CA1 activity encodes navigationally relevant information and the extent to which it relates to behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.