Evidence map›Paper›PMID 29149608›Full record

ArticleCell2017

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

Meromit Singer, Chao Wang, Le Cong, Nemanja D Marjanovic, Monika S Kowalczyk, Huiyuan Zhang, Jackson Nyman, Kaori Sakuishi, Sema Kurtulus, David Gennert and 9 more

Abstract readPublished Erratum
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. MX1Journal of translational medicine · 2026
    Article
  2. Review
  3. A STUB1-CHIC2 complex inhibits CD8Nature immunology · 2025
    Article
  4. Article
  5. PD-1 involvement in CD8+ tumor-infiltrating lymphocytes in patients with colonic-derived peritoneal adenocarcinoma.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  6. Circulating tumor-reactive KIRNature immunology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Ionic Regulation of T-Cell Function and Anti-Tumour Immunity.International journal of molecular sciences · 2021
    Review
  17. Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Meromit Singer
Chao Wang
Le Cong
Nemanja D Marjanovic
Monika S Kowalczyk
Huiyuan Zhang
Jackson Nyman
Kaori Sakuishi
Sema Kurtulus
David Gennert
Junrong Xia
John Y H Kwon
James Nevin
Rebecca H Herbst
Itai Yanai
Orit Rozenblatt-Rosen
Vijay K Kuchroo
Aviv Regev
Ana C Anderson

Funding

Transgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BEHAR, SAMUEL M · 2008 to 2019
$17.1M
Role of Th1 specific cell surface molecule Tim-3 in EAE.R01NS045937 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2003 to 2016
$4.9M
Role of Tim-3 in determining T cell immunityR01CA187975 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, ANA C · 2015 to 2025
$3.9M
NCI NIH HHS R01 CA187975NIAID NIH HHS P01 AI073748NINDS NIH HHS R01 NS045937
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID29149608
PMCPMC5788298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.